IL1R1
IL1R1(為Interleukin-1 Receptor Type 1)是白細(xì)胞介素-1(Interleukin-1,IL-1)家族中的一員。 結(jié)構(gòu)是一個(gè)單一的跨膜蛋白,含有外部區(qū)域、跨膜區(qū)和胞內(nèi)區(qū)域。外部區(qū)域包括多個(gè)結(jié)構(gòu)域,如三個(gè)免疫球蛋白結(jié)構(gòu)域(Ig-like domains),用于與細(xì)胞因子結(jié)合。當(dāng)機(jī)體遭受感染、損傷或其他炎癥刺激時(shí),細(xì)胞會(huì)產(chǎn)生IL-1,然后IL-1與IL1R1在細(xì)胞表面結(jié)合,形成IL-1/IL1R1復(fù)合體。這個(gè)復(fù)合體激活了細(xì)胞內(nèi)的信號(hào)轉(zhuǎn)導(dǎo)通路,如NF-κB和MAPK等,從而引發(fā)炎癥反應(yīng)和免疫應(yīng)答。 IL1R1在免疫調(diào)節(jié)和炎癥過(guò)程中起著重要作用。它在許多炎癥性和免疫性疾病中發(fā)揮著關(guān)鍵的調(diào)控作用,如風(fēng)濕性關(guān)節(jié)炎、炎癥性腸病、類(lèi)風(fēng)濕性關(guān)節(jié)炎等。因此,IL1R1成為了治療這些疾病的一個(gè)潛在靶點(diǎn)。
更多相關(guān)閱讀:轉(zhuǎn)鐵蛋白受體TFR1(TFRC):鐵穩(wěn)態(tài)關(guān)鍵成員,貧血、神經(jīng)退行性疾病、癌癥新銳靶點(diǎn)!
熱銷(xiāo)產(chǎn)品
● IL1R1 Recombinant Monoclonal Antibody CSB-RA011621MA1HU
驗(yàn)證數(shù)據(jù)
Overlay Peak curve showing NIH/3T3 cells stained with CSB-RA011621MA1HU (red line) at 1:50. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
● Recombinant Human Interleukin-1 receptor type 1(IL1R1) CSB-CF011621HU
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IL1R1 Antibodies
IL1R1 for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
---|---|---|---|
CSB-PA011621ESR1HU | IL1R1 Antibody | Human, Mouse | ELISA, WB, IHC |
CSB-PA011621ESR2HU | IL1R1 Antibody | Human | ELISA, IHC |
CSB-PA005251 | IL1R1 Antibody | Human | WB, ELISA |
CSB-PA009540 | Phospho-IL1R1 (Y496) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA727952 | IL1R1 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA072110 | IL1R1 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA011621EA01HU | IL1R1 Antibody | Human | ELISA, WB, IF |
CSB-PA011621EB01HU | IL1R1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA011621EC01HU | IL1R1 Antibody, FITC conjugated | Human | |
CSB-PA011621ED01HU | IL1R1 Antibody, Biotin conjugated | Human | ELISA |
CSB-RA011621MA1HU | IL1R1 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, FC |
IL1R1 Proteins
IL1R1 Proteins for Mus musculus (Mouse)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
---|---|---|
CSB-YP011621MO1 CSB-EP011621MO1 CSB-BP011621MO1 CSB-MP011621MO1 CSB-EP011621MO1-B |
Recombinant Mouse Interleukin-1 receptor type 1 (Il1r1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF011621MO | Recombinant Mouse Interleukin-1 receptor type 1 (Il1r1) | in vitro E.coli expression system |
IL1R1 Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
---|---|---|
CSB-YP011621HU CSB-EP011621HU CSB-BP011621HU CSB-EP011621HU-B |
Recombinant Human Interleukin-1 receptor type 1 (IL1R1), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-CF011621HU | Recombinant Human Interleukin-1 receptor type 1 (IL1R1) | in vitro E.coli expression system |
CSB-MP011621HU | Recombinant Human Interleukin-1 receptor type 1 (IL1R1)-VLPs | Mammalian cell |
IL1R1 ELISA Kit
IL1R1 ELISA Kit for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
---|---|---|---|
CSB-E04611h | Human soluble interleukin-1 receptor Ⅰ,IL-1sRⅠ ELISA kit | serum, plasma,tissue homogenates | 0.039 ng/ml |