INVS

Inversin是人體中由INVS基因編碼的一種蛋白質(zhì)。它在正常腎臟發(fā)育和左右軸的建立中起著必要作用?？赡茏鳛椴煌琖nt信號通路之間的分子開關。通過靶向細胞質(zhì)中的Disheveled（DVL1）使其被泛素蛋白酶降解，從而抑制了經(jīng)典Wnt通路。這表明，在腎臟發(fā)育中，它在對抗Wnt信號抑制小管上皮細胞末期分化方面是必要的。與NPHP1、NPHP4和RPGRIP1L/NPHP8（類似物）共同參與調(diào)節(jié)腎細胞頂部結合的組織。似乎不是纖毛發(fā)生的嚴格必需品（類似）。

Inversin is a protein in humans that is encoded by INVS gene. Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).