ITGA2B

ITGA2，即整合素亞基α2b，別名血小板膜糖蛋白IIb（GPIIb）、CD41B、αIIbβ3整合素的α亞基。ITGA2B是一種細(xì)胞表面受體，由ITGA2B基因編碼，屬于整合素α鏈家族成員之一。它在血小板中與β3亞基（ITGB3）非共價(jià)結(jié)合，形成αIIbβ3整合素，這是血小板聚集和血液凝固的關(guān)鍵受體。ITGA2B的作用機(jī)制涉及與多種配體的結(jié)合，如纖維蛋白原、纖維連接蛋白、凝血酶原、血小板反應(yīng)蛋白和玻璃連接蛋白，通過識(shí)別特定的氨基酸序列如R-G-D和H-H-L-G-G-G-A-K-Q-A-G-D-V。ITGA2B在生物學(xué)上的意義非常廣泛，它在血液凝固、傷口愈合、炎癥反應(yīng)和細(xì)胞遷移等過程中發(fā)揮重要作用。αIIbβ3整合素作為血小板的主要聚集受體，參與血小板與血管損傷部位的粘附和聚集，對(duì)維持血液流動(dòng)性和防止出血至關(guān)重要。此外，ITGA2B的功能異常與多種疾病有關(guān)，包括Glanzmann血栓減少癥（一種遺傳性血小板功能障礙疾病）和其他出血性疾病。因此，ITGA2B是血液學(xué)研究和相關(guān)疾病治療中的一個(gè)重要靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Integrin alpha-IIb (ITGA2B), partial (CSB-EP011865HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ITGA2B Antibody (CSB-PA011865LA01HU)

驗(yàn)證數(shù)據(jù)

Immunofluorescence staining of A549 cells with CSB-PA011865LA01HU at 1:400, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA011865LA01HU at dilution of 1:100

Human Integrin alpha-IIb(ITGA2B) ELISA kit (CSB-EL011865HU)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-EL011865HU

規(guī)格：96T/48T

靈敏度：0.039 ng/mL

檢測(cè)范圍：0.156 ng/mL-10 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ITGA2B Antibody

ITGA2B Protein

ITGA2B ELISA Kit

ITGA2B Antibodies

ITGA2B for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA011865LA01HU	ITGA2B Antibody	Human	ELISA, IHC, IF
CSB-PA011865LB01HU	ITGA2B Antibody, HRP conjugated	Human	ELISA
CSB-PA011865LC01HU	ITGA2B Antibody, FITC conjugated	Human
CSB-PA011865LD01HU	ITGA2B Antibody, Biotin conjugated	Human	ELISA
CSB-PA249653	ITGA2B Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA729448	ITGA2B Antibody	Human,Mouse	ELISA,WB

ITGA2B for Human

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-MA000265	ITGA2B Monoclonal Antibody	Human	ELISA,IHC

ITGA2B Proteins

ITGA2B Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP011865HU	Recombinant Human Integrin alpha-IIb (ITGA2B), partial	Yeast
CSB-EP011865HU	Recombinant Human Integrin alpha-IIb (ITGA2B), partial	E.coli
CSB-BP011865HU CSB-MP011865HU CSB-EP011865HU-B	Recombinant Human Integrin alpha-IIb (ITGA2B), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ITGA2B Proteins for Papio cynocephalus (Yellow baboon)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP011865PBR CSB-EP011865PBR CSB-BP011865PBR CSB-MP011865PBR CSB-EP011865PBR-B	Recombinant Papio cynocephalus Integrin alpha-IIb (ITGA2B), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ITGA2B Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP865567MO CSB-EP865567MO CSB-BP865567MO CSB-MP865567MO CSB-EP865567MO-B	Recombinant Mouse Integrin alpha-IIb (Itga2b), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli