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ITGA6

ITGA6,即整合素亞基α6,別名 Alpha6p、CD49f、VLA-6。它是一種細(xì)胞表面糖蛋白,由ITGA6基因編碼,屬于整合素家族的α亞基成員,在多種上皮細(xì)胞中表達(dá)。ITGA6與β4整合素鏈結(jié)合形成α6β4整合素,參與細(xì)胞與細(xì)胞外基質(zhì)的粘附,特別是與層粘連蛋白的相互作用。其作用機(jī)制主要是通過介導(dǎo)細(xì)胞間的相互作用和信號(hào)傳導(dǎo),參與細(xì)胞遷移、增殖和組織再生等過程。ITGA6在維持上皮完整性、調(diào)控免疫反應(yīng)及傷口愈合中發(fā)揮重要作用。異常表達(dá)的ITGA6與某些疾病如交界性大皰性表皮松解癥、某些癌癥和纖維化疾病相關(guān),是相關(guān)疾病研究和治療的潛在靶點(diǎn)。

熱銷產(chǎn)品

ITGA6 Recombinant Monoclonal Antibody (CSB-RA172768A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA172768A0HU

Immunofluorescence staining of MCF-7 cell with CSB-RA172768A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 536-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA172768A0HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA172768A0HU (red line) at 1:100. The cells were incubated in 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

ITGA6 Antibodies

ITGA6 for Homo sapiens (Human)

ITGA6 Proteins

ITGA6 Proteins for Gallus gallus (Chicken)

ITGA6 Proteins for Homo sapiens (Human)

ITGA6 Proteins for Mus musculus (Mouse)