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ITGAV

ITGAV,即整合素α亞基CD51,別名CD51、Integrin alpha-V、Vitronectin receptor alpha鏈等。ITGAV基因位于人類12號(hào)染色體上,編碼的蛋白質(zhì)是整合素家族成員之一,主要參與細(xì)胞與細(xì)胞外基質(zhì)的粘附。ITGAV的作用機(jī)制是通過(guò)與不同的β亞單位結(jié)合形成異二聚體,如與β3亞單位結(jié)合形成αvβ3整合素,參與多種生物學(xué)過(guò)程,包括細(xì)胞黏附、遷移、增殖和信號(hào)傳導(dǎo)。ITGAV在多種細(xì)胞類型中表達(dá),如內(nèi)皮細(xì)胞、上皮細(xì)胞、膠質(zhì)細(xì)胞、肌細(xì)胞、滋養(yǎng)層細(xì)胞和免疫細(xì)胞等,在腫瘤發(fā)展過(guò)程中發(fā)揮著關(guān)鍵作用,如促進(jìn)細(xì)胞粘附和遷移。ITGAV的表達(dá)水平在多種腫瘤中發(fā)生變化,與腫瘤的侵襲、轉(zhuǎn)移和預(yù)后密切相關(guān),是研究和治療腫瘤的重要靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Integrin alpha-V (ITGAV), partial (CSB-YP011877HU)

驗(yàn)證數(shù)據(jù)

CSB-YP011877HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ITGAV Recombinant Monoclonal Antibody (CSB-RA279866A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA279866A0HU

Western Blot
Positive WB detected in: U-251 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate
All lanes: ITGAV antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 117, 113, 112 kDa
Observed band size: 130 kDa

CSB-RA279866A0HU

IHC image of CSB-RA279866A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

ITGAV Antibodies

ITGAV for Homo sapiens (Human)

ITGAV Proteins

ITGAV Proteins for Bos taurus (Bovine)

ITGAV Proteins for Mus musculus (Mouse)

ITGAV Proteins for Gallus gallus (Chicken)

ITGAV Proteins for Homo sapiens (Human)