ITGAV
ITGAV，即整合素α亞基CD51，別名CD51、Integrin alpha-V、Vitronectin receptor alpha鏈等。ITGAV基因位于人類12號(hào)染色體上，編碼的蛋白質(zhì)是整合素家族成員之一，主要參與細(xì)胞與細(xì)胞外基質(zhì)的粘附。ITGAV的作用機(jī)制是通過(guò)與不同的β亞單位結(jié)合形成異二聚體，如與β3亞單位結(jié)合形成αvβ3整合素，參與多種生物學(xué)過(guò)程，包括細(xì)胞黏附、遷移、增殖和信號(hào)傳導(dǎo)。ITGAV在多種細(xì)胞類型中表達(dá)，如內(nèi)皮細(xì)胞、上皮細(xì)胞、膠質(zhì)細(xì)胞、肌細(xì)胞、滋養(yǎng)層細(xì)胞和免疫細(xì)胞等，在腫瘤發(fā)展過(guò)程中發(fā)揮著關(guān)鍵作用，如促進(jìn)細(xì)胞粘附和遷移。ITGAV的表達(dá)水平在多種腫瘤中發(fā)生變化，與腫瘤的侵襲、轉(zhuǎn)移和預(yù)后密切相關(guān)，是研究和治療腫瘤的重要靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Integrin alpha-V (ITGAV), partial (CSB-YP011877HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ITGAV Recombinant Monoclonal Antibody (CSB-RA279866A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: U-251 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate
All lanes: ITGAV antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 117, 113, 112 kDa
Observed band size: 130 kDa
IHC image of CSB-RA279866A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
ITGAV Antibodies
ITGAV for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA000074 | Cleaved-ITGAV (K889) Antibody | Human | WB, ELISA |
| CSB-PA003047 | ITGAV Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA011877LA01HU | ITGAV Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA011877LB01HU | ITGAV Antibody, HRP conjugated | Human | ELISA |
| CSB-PA011877LC01HU | ITGAV Antibody, FITC conjugated | Human | |
| CSB-PA011877LD01HU | ITGAV Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA548303A0HU | ITGAV Recombinant Monoclonal Antibody | Human | ELISA, IHC |
| CSB-RA279866A0HU | ITGAV Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
| CSB-RA011877MA1HU | ITGAV Recombinant Monoclonal Antibody | Human, Mouse | ELISA, IF, FC |
ITGAV Proteins
ITGAV Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011877BO CSB-EP011877BO CSB-BP011877BO CSB-MP011877BO CSB-EP011877BO-B |
Recombinant Bovine Integrin alpha-V (ITGAV), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGAV Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011877MO CSB-EP011877MO CSB-BP011877MO CSB-MP011877MO CSB-EP011877MO-B |
Recombinant Mouse Integrin alpha-V (Itgav), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGAV Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011877CH CSB-EP011877CH CSB-BP011877CH CSB-MP011877CH CSB-EP011877CH-B |
Recombinant Chicken Integrin alpha-V (ITGAV), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGAV Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011877HU | Recombinant Human Integrin alpha-V (ITGAV), partial | Yeast |
| CSB-EP011877HU CSB-BP011877HU CSB-MP011877HU CSB-EP011877HU-B |
Recombinant Human Integrin alpha-V (ITGAV), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
