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JAK2

JAK2,即Janus激酶2,別名Janus kinase 2 、JTK10、THCYT3。它是一種細(xì)胞質(zhì)中的非受體型酪氨酸蛋白激酶,廣泛分布于體細(xì)胞的胞質(zhì)中,參與造血和免疫系統(tǒng)等的信號(hào)轉(zhuǎn)導(dǎo),對(duì)紅細(xì)胞的生成及免疫細(xì)胞的活化也有重要作用。JAK2的作用機(jī)制主要是通過與多種細(xì)胞因子受體相關(guān)聯(lián),當(dāng)細(xì)胞因子與其受體結(jié)合后,JAK2被激活并觸發(fā)下游的JAK-STAT信號(hào)通路,參與細(xì)胞的增殖、分化、凋亡及免疫調(diào)節(jié)等眾多生物學(xué)過程。JAK2的異常激活與多種血液系統(tǒng)惡性腫瘤的發(fā)生發(fā)展有關(guān),尤其是與骨髓增殖性腫瘤(myeloproliferative neoplasms, MPNs)密切相關(guān),JAK2激酶的突變,如假激酶區(qū)V617F的位點(diǎn)突變,是誘發(fā)MPNs的重要原因。AK2是治療MPNs的重要靶標(biāo),通過抑制JAK2-STAT信號(hào)通路的異常激活來治療MPNs已成為熱門研究方向。

熱銷產(chǎn)品

Recombinant Human Tyrosine-protein kinase JAK2 (JAK2), partial (CSB-EP011931HU)

驗(yàn)證數(shù)據(jù)

CSB-EP011931HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP011931HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP011931HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) JAK2.

CSB-EP011931HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP011931HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) JAK2.

JAK2 Recombinant Monoclonal Antibody (CSB-RA267127A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA267127A0HU

Immunofluorescence staining of Hela Cells with CSB-RA267127A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

JAK2 Antibodies

JAK2 for Homo sapiens (Human)

JAK2 Proteins

JAK2 Proteins for Sus scrofa (Pig)

JAK2 Proteins for Homo sapiens (Human)

JAK2 Proteins for Pongo abelii (Sumatran orangutan)

JAK2 Proteins for Rattus norvegicus (Rat)

JAK2 Proteins for Mus musculus (Mouse)

JAK2 Proteins for Gallus gallus (Chicken)