KLB
KLB(Klotho β),也稱(chēng)為β-klotho,是一種跨膜蛋白,具有多個(gè)結(jié)構(gòu)域,這些結(jié)構(gòu)域在不同的活性環(huán)境中發(fā)揮著不同的功能。KLB在調(diào)節(jié)礦物質(zhì)代謝、細(xì)胞信號(hào)傳導(dǎo)和衰老過(guò)程中起著重要作用。它與FGF23共同作用,影響磷酸鹽的重吸收和維生素D的活化,同時(shí)可能通過(guò)影響Wnt/β-catenin信號(hào)通路中的β-catenin穩(wěn)定性來(lái)調(diào)節(jié)細(xì)胞增殖和分化。此外,KLB還可能與TGF-β家族成員相互作用,參與調(diào)節(jié)細(xì)胞外基質(zhì)的合成和分解,影響組織修復(fù)和纖維化過(guò)程。KLB的異常表達(dá)或功能失調(diào)與多種疾病相關(guān),包括慢性腎病、心血管疾病和衰老相關(guān)的疾病,使其成為生物醫(yī)學(xué)研究中的一個(gè)有前景的靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
KLB Antibody (CSB-PA769815LA01HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-PA769815LA01HU diluted at 1:200 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA769815LA01HU diluted at 1:200 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of HepG2 cells with CSB-PA769815LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
KLB Antibodies
KLB for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
---|---|---|---|
CSB-PA769815LA01HU | KLB Antibody | Human | ELISA, IHC, IF |
CSB-PA769815LB01HU | KLB Antibody, HRP conjugated | Human | ELISA |
CSB-PA769815LC01HU | KLB Antibody, FITC conjugated | Human | |
CSB-PA769815LD01HU | KLB Antibody, Biotin conjugated | Human | ELISA |
KLB Proteins
KLB Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
---|---|---|
CSB-YP769815HU CSB-EP769815HU CSB-BP769815HU CSB-MP769815HU CSB-EP769815HU-B |
Recombinant Human Beta-klotho (KLB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLB ELISA Kit
KLB ELISA Kit for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
---|---|---|---|
CSB-EL012378HU | Human Beta-klotho(KLB) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 15.6 pg/mL |