LILRB4
LILRB4（白細(xì)胞免疫球蛋白樣受體B4）是一種免疫檢查點(diǎn)分子，屬于白細(xì)胞免疫球蛋白樣受體家族B亞家族成員。它由胞外免疫球蛋白樣結(jié)構(gòu)域、一個(gè)跨膜結(jié)構(gòu)域以及含有免疫受體酪氨酸抑制基序（ITIMs）的細(xì)胞質(zhì)結(jié)構(gòu)域組成。LILRB4在多種免疫細(xì)胞上表達(dá)，包括單核細(xì)胞、巨噬細(xì)胞、肥大細(xì)胞、B細(xì)胞、自然殺傷細(xì)胞、T細(xì)胞和樹突細(xì)胞等，具有調(diào)控免疫細(xì)胞活性、促進(jìn)腫瘤免疫逃逸的功能。LILRB4通過與配體如整合素αvβ3結(jié)合，抑制肥大細(xì)胞活化，并通過其胞質(zhì)結(jié)構(gòu)域中的ITIMs傳遞抑制信號(hào)，抑制免疫細(xì)胞活性。此外，LILRB4還可能通過招募SHP1來抑制NF-κB信號(hào)通路，這在動(dòng)脈粥樣硬化的發(fā)生中可能起抑制作用。LILRB4的表達(dá)和功能在不同疾病中具有重要意義，尤其是在癌癥治療中，靶向LILRB4的抗體可能有助于抑制腫瘤免疫逃逸，提高免疫治療的效果。因此，LILRB4是免疫治療研究中的一個(gè)潛在靶點(diǎn)，其結(jié)構(gòu)和功能的研究有助于開發(fā)新的治療策略。
熱銷產(chǎn)品
LILRB4 Antibody (CSB-PA850914ESR2HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: A549 whole cell lysate, THP-1 whole cell lysate
All lanes: LILRB4 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 50 kDa
Observed band size: 50 kDa
IHC image of CSB-PA850914ESR2HU diluted at 1:250 and staining in paraffin-embedded human colorectal cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
LILRB4 Antibodies
LILRB4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA297929 | LILRB4 Antibody | Human | ELISA,IF |
| CSB-PA006757 | LILRB4 Antibody | Human | IF, ELISA |
| CSB-PA850914ESR1HU | LILRB4 Antibody | Human | ELISA, WB |
| CSB-PA850914ESR2HU | LILRB4 Antibody | Human | ELISA, WB, IHC |
LILRB4 Proteins
LILRB4 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP731041MO CSB-EP731041MO CSB-BP731041MO CSB-MP731041MO CSB-EP731041MO-B |
Recombinant Mouse Leukocyte immunoglobulin-like receptor subfamily B member 4 (Lilrb4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LILRB4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP850914HU CSB-EP850914HU CSB-BP850914HU CSB-MP850914HU CSB-EP850914HU-B |
Recombinant Human Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LILRB4 ELISA Kit
LILRB4 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11812h | Human leukocyte immunoglobulin-like receptor subfamily B member 4,LILRB4 ELISA Kit | serum, plasma, cell culture supernates, cell lysates | 7.81 pg/mL |
