Your Good Partner in Biology Research

LILRB4

LILRB4(白細(xì)胞免疫球蛋白樣受體B4)是一種免疫檢查點(diǎn)分子,屬于白細(xì)胞免疫球蛋白樣受體家族B亞家族成員。它由胞外免疫球蛋白樣結(jié)構(gòu)域、一個(gè)跨膜結(jié)構(gòu)域以及含有免疫受體酪氨酸抑制基序(ITIMs)的細(xì)胞質(zhì)結(jié)構(gòu)域組成。LILRB4在多種免疫細(xì)胞上表達(dá),包括單核細(xì)胞、巨噬細(xì)胞、肥大細(xì)胞、B細(xì)胞、自然殺傷細(xì)胞、T細(xì)胞和樹突細(xì)胞等,具有調(diào)控免疫細(xì)胞活性、促進(jìn)腫瘤免疫逃逸的功能。LILRB4通過與配體如整合素αvβ3結(jié)合,抑制肥大細(xì)胞活化,并通過其胞質(zhì)結(jié)構(gòu)域中的ITIMs傳遞抑制信號(hào),抑制免疫細(xì)胞活性。此外,LILRB4還可能通過招募SHP1來抑制NF-κB信號(hào)通路,這在動(dòng)脈粥樣硬化的發(fā)生中可能起抑制作用。LILRB4的表達(dá)和功能在不同疾病中具有重要意義,尤其是在癌癥治療中,靶向LILRB4的抗體可能有助于抑制腫瘤免疫逃逸,提高免疫治療的效果。因此,LILRB4是免疫治療研究中的一個(gè)潛在靶點(diǎn),其結(jié)構(gòu)和功能的研究有助于開發(fā)新的治療策略。

熱銷產(chǎn)品

LILRB4 Antibody (CSB-PA850914ESR2HU)

驗(yàn)證數(shù)據(jù)

CSB-PA850914ESR2HU

Western Blot
Positive WB detected in: A549 whole cell lysate, THP-1 whole cell lysate
All lanes: LILRB4 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 50 kDa
Observed band size: 50 kDa

CSB-PA850914ESR2HU

IHC image of CSB-PA850914ESR2HU diluted at 1:250 and staining in paraffin-embedded human colorectal cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

LILRB4 Antibodies

LILRB4 for Homo sapiens (Human)

LILRB4 Proteins

LILRB4 Proteins for Mus musculus (Mouse)

LILRB4 Proteins for Homo sapiens (Human)

LILRB4 ELISA Kit

LILRB4 ELISA Kit for Homo sapiens (Human)