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LONP1

LONP1,即線粒體ATP依賴性蛋白酶,別名PIM1、Protease serine 15、PRSS15、Serine protease 15。它是一種由LONP1基因編碼的線粒體蛋白酶,具有蛋白水解、分子伴侶和mtDNA結(jié)合等多重功能。LONP1通過降解錯(cuò)誤折疊或損壞的蛋白質(zhì)來維持線粒體蛋白質(zhì)的穩(wěn)態(tài),參與調(diào)節(jié)氧化應(yīng)激反應(yīng)、熱休克反應(yīng)以及線粒體DNA的穩(wěn)定性。LONP1在心臟保護(hù)、腫瘤進(jìn)展、代謝調(diào)控等生物學(xué)過程中發(fā)揮重要作用,其活性的變化與多種疾病的發(fā)生發(fā)展密切相關(guān),是細(xì)胞生理和病理研究中的關(guān)鍵分子。

熱銷產(chǎn)品

Recombinant Human Lon protease homolog, mitochondrial (LONP1), partial (CSB-EP013032HU)

驗(yàn)證數(shù)據(jù)

CSB-EP013032HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LONP1 Antibodies

LONP1 for Homo sapiens (Human)

LONP1 Proteins

LONP1 Proteins for Homo sapiens (Human)