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METTL14

METTL14,即甲基轉(zhuǎn)移酶樣蛋白14,別名KIAA1539。它是一種由METTL14基因編碼的蛋白質(zhì),具有甲基化轉(zhuǎn)移酶活性,參與RNA的m6A甲基化修飾。METTL14的作用機(jī)制是通過其甲基化活性,特異性地在RNA分子的腺苷酸上添加甲基,形成N6-甲基腺苷酸(m6A),這種修飾在調(diào)控mRNA的穩(wěn)定性、剪接、轉(zhuǎn)運(yùn)和翻譯中發(fā)揮作用。METTL14的功能異常與多種疾病有關(guān),尤其是在癌癥中,METTL14的異常表達(dá)或活性改變可能導(dǎo)致腫瘤細(xì)胞的增殖和轉(zhuǎn)移。此外,METTL14在神經(jīng)系統(tǒng)發(fā)育和認(rèn)知功能中也發(fā)揮作用,其突變與某些神經(jīng)發(fā)育障礙相關(guān)。

熱銷產(chǎn)品

Recombinant Human N6-adenosine-methyltransferase non-catalytic subunit (METTL14) (CSB-EP884519HU)

驗(yàn)證數(shù)據(jù)

CSB-EP884519HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

METTL14 Antibody (CSB-PA884519LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA884519LA01HU

Western Blot
Positive WB detected in: SH-SY5Y whole cell lysate
All lanes: METTL14 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 53 kDa
Observed band size: 53 kDa

METTL14 Antibodies

METTL14 for Homo sapiens (Human)

METTL14 Proteins

METTL14 Proteins for Bos taurus (Bovine)

METTL14 Proteins for Mus musculus (Mouse)

METTL14 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

METTL14 Proteins for Gallus gallus (Chicken)

METTL14 Proteins for Pongo abelii (Sumatran orangutan)

METTL14 Proteins for Xenopus laevis (African clawed frog)

METTL14 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

METTL14 Proteins for Homo sapiens (Human)