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MPL

MPL,即巨核細胞增生性白血病病毒受體,別名Myeloproliferative Leukemia Virus Receptor、CD110等。MPL是一種表達于造血干細胞、早期髓系和淋巴系前體細胞、內(nèi)皮細胞以及某些腫瘤細胞表面的細胞表面受體。它屬于腫瘤壞死因子受體超家族成員,由人體細胞自身的基因編碼。MPL的作用機制主要涉及與多種配體結(jié)合,如TPO(血小板生成素)、ELN(內(nèi)皮細胞白血病抑制因子)等,這些配體的結(jié)合能夠激活MPL,進而觸發(fā)下游的JAK2/STAT、MAPK等信號通路,促進巨核細胞的增殖和分化,影響血小板的生成。MPL在正常的造血過程中發(fā)揮著關(guān)鍵作用,尤其是在血小板的生成和功能的維持中。MPL的激活可以促進巨核細胞的增殖和成熟,從而增加血小板的產(chǎn)生。此外,MPL還參與了對炎癥反應(yīng)、血管生成和免疫調(diào)節(jié)等過程的調(diào)控。MPL的功能異常與某些骨髓增生性疾病的發(fā)生發(fā)展有關(guān),如原發(fā)性血小板增多癥、骨髓增生異常綜合征等。因此,MPL是血液學(xué)研究和相關(guān)疾病治療中的一個潛在靶點。

熱銷產(chǎn)品

Recombinant Human Thrombopoietin receptor (MPL), partial (CSB-EP014755HU)

驗證數(shù)據(jù)

CSB-EP014755HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

MPL Antibody (CSB-PA014755LA01HU)

驗證數(shù)據(jù)

CSB-PA014755LA01HU

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA014755LA01HU at dilution of 1:100

CSB-PA014755LA01HU

Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA014755LA01HU at dilution of 1:100

CSB-PA014755LA01HU

Immunofluorescent analysis of A549 cells using CSB-PA014755LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

MPL Antibodies

MPL for Homo sapiens (Human)

MPL Proteins

MPL Proteins for Homo sapiens (Human)

MPL Proteins for Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

MPL Proteins for Listeria monocytogenes

MPL Proteins for Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

MPL Proteins for Escherichia coli (strain K12)

MPL Proteins for Mus musculus (Mouse)