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MSTN

MSTN,即肌生長(zhǎng)抑制素,是一種在哺乳動(dòng)物肌肉骨骼系統(tǒng)中起關(guān)鍵調(diào)控作用的分泌性蛋白,屬于TGF-β超家族成員。其結(jié)構(gòu)包括N-末端的分泌信號(hào)肽和半胱氨酸結(jié)構(gòu)。MSTN通過(guò)與其受體結(jié)合,抑制肌肉細(xì)胞的生長(zhǎng)、分化和增殖,從而調(diào)控肌肉的發(fā)育。在信號(hào)轉(zhuǎn)導(dǎo)過(guò)程中,MSTN與胞質(zhì)內(nèi)受體形成復(fù)合物,進(jìn)而激活Smads蛋白,使其磷酸化并進(jìn)入細(xì)胞核調(diào)節(jié)靶基因表達(dá)。此外,MSTN還涉及MAPK和p38等信號(hào)通路的轉(zhuǎn)導(dǎo),對(duì)肌肉細(xì)胞增殖周期產(chǎn)生影響。MSTN的復(fù)雜結(jié)構(gòu)和功能使其在生物學(xué)和醫(yī)學(xué)領(lǐng)域具有廣泛的應(yīng)用前景,尤其在肌肉生長(zhǎng)調(diào)控、疾病治療及肉化劑開(kāi)發(fā)等方面。

熱銷(xiāo)產(chǎn)品

Recombinant Horse Growth/differentiation factor 8 (MSTN)

驗(yàn)證數(shù)據(jù)

SDS
CSB-EP861952HO SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.


MSTN Antibodies

MSTN for Homo sapiens (Human)

MSTN Proteins

MSTN Proteins for Homo sapiens (Human)

MSTN ELISA Kit

MSTN ELISA Kit for Homo sapiens (Human)