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NCR1

NCR1,即自然細胞毒性觸發(fā)受體1,別名NKp46、CD335、LY94。它是一種免疫球蛋白超家族成員,具有兩個細胞外免疫球蛋白樣域,屬于I型跨膜受體。NCR1由人類19號染色體上的基因編碼,位于Leukocyte Receptor Complex (LRC) 區(qū)域。NCR1的作用機制是通過與腫瘤細胞或病毒感染細胞表面的配體結(jié)合,激活NK細胞的細胞毒性和細胞因子分泌功能,從而參與機體的免疫監(jiān)視和防御反應 。NCR1在生物學上的意義體現(xiàn)在其對自然殺傷(NK)細胞功能的重要調(diào)控作用。NK細胞通過NCR1識別腫瘤或病毒感染細胞,進而發(fā)揮殺傷作用。NCR1的表達和功能對于維持機體的免疫平衡和防御能力至關(guān)重要。此外,NCR1還可能在其他免疫細胞亞群中發(fā)揮作用,如某些類型的T細胞和固有淋巴細胞(ILCs),這為開發(fā)新的免疫治療策略提供了潛在靶點 。

熱銷產(chǎn)品

NCR1 Antibody (CSB-PA015549LA01HU)

驗證數(shù)據(jù)

CSB-PA015549LA01HU

Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA015549LA01HU at dilution of 1:100

CSB-PA015549LA01HU

Immunofluorescent analysis of A549 cells using CSB-PA015549LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

NCR1 Antibodies

NCR1 for Homo sapiens (Human)

NCR1 Proteins

NCR1 Proteins for Homo sapiens (Human)

NCR1 Proteins for Bos taurus (Bovine)

NCR1 Proteins for Mus musculus (Mouse)

NCR1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

NCR1 Proteins for Rattus norvegicus (Rat)

NCR1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)