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NF2

NF2,即神經纖維瘤病2型,別名 ACN、BANF、Merlin。它來源于一種名為NF2的基因突變,這種突變主要影響位于22號染色體上的NF2基因,該基因編碼的Merlin蛋白具有腫瘤抑制功能。當NF2基因發(fā)生突變時,Merlin蛋白的功能受損,導致細胞對腫瘤生長的抑制作用減弱,進而增加神經系統(tǒng)腫瘤(如前庭神經鞘瘤、腦膜瘤等)的風險。NF2揭示了特定基因突變與神經系統(tǒng)腫瘤發(fā)生之間的關聯(lián),為疾病的早期診斷、治療和遺傳咨詢提供了重要依據。

熱銷產品

Recombinant Human Merlin (NF2) (CSB-EP015741HU)

驗證數據

CSB-EP015741HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NF2 Antibody (CSB-PA015741LA01HU)

驗證數據

CSB-PA015741LA01HU

Western Blot
Positive WB detected in: HEK293 whole cell lysate, Jurkat whole cell lysate, MCF-7 whole cell lysate, NIH/3T3 whole cell lysate
All lanes: NF2 antibody at 2.6μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 70, 73, 60, 65, 64, 31, 66, 20, 25 kDa
Observed band size: 70, 73 kDa

CSB-PA015741LA01HU

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA015741LA01HU at dilution of 1:100

CSB-PA015741LA01HU

Immunofluorescent analysis of Hela cells using CSB-PA015741LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

NF2 Antibodies

NF2 for Homo sapiens (Human)

NF2 Proteins

NF2 Proteins for Homo sapiens (Human)

NF2 Proteins for Mus musculus (Mouse)

NF2 Proteins for Papio anubis (Olive baboon)

NF2 Proteins for Rattus norvegicus (Rat)