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PAX6

PAX6,即配對(duì)框基因6,是一種在進(jìn)化上高度保守的轉(zhuǎn)錄因子,由PAX6基因編碼。它在眼睛、大腦、鼻子和胰腺等器官的發(fā)育中起著至關(guān)重要的作用。PAX6通過結(jié)合特定的DNA序列,調(diào)控下游基因的表達(dá),從而參與多種生物學(xué)過程,包括胚胎發(fā)育和器官形成。PAX6的功能異常與多種眼部疾病相關(guān),如先天性白內(nèi)障、無虹膜和小眼球癥等。此外,PAX6還涉及到腫瘤發(fā)生等過程,其在腫瘤中的表達(dá)變化可能影響腫瘤細(xì)胞的增殖和分化。PAX6參與的信號(hào)通路包括但不限于MEK/ERK信號(hào)通路,該通路在肝星狀細(xì)胞的活化和增殖中發(fā)揮作用??偟膩碚f,PAX6是一個(gè)多功能的調(diào)控分子,對(duì)維持生物體的正常發(fā)育和生理功能至關(guān)重要。

熱銷產(chǎn)品

Recombinant Human Paired box protein Pax-6 (PAX6) (CSB-EP017492HU)

驗(yàn)證數(shù)據(jù)

CSB-EP017492HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PAX6 Recombinant Monoclonal Antibody (CSB-RA577229A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA577229A0HU

IHC image of CSB-RA577229A0HU diluted at 1:100 and staining in paraffin-embedded human pancreati tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.55% DAB.

CSB-RA577229A0HU

IHC image of CSB-RA577229A0HU diluted at 1:100 and staining in paraffin-embedded human glioma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.55% DAB.

CSB-RA577229A0HU

Overlay Peak curve showing SH-SY5Y cells stained with CSB-RA577229A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

Mouse paired box 6 (PAX6) ELISA kit (CSB-EL017492MO)

驗(yàn)證數(shù)據(jù)

CSB-EL017492MO 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-EL017492MO

規(guī)格:96T/48T

靈敏度:11.72 pg/mL

檢測(cè)范圍:46.88 pg/mL-3000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

PAX6 Antibodies

PAX6 for Homo sapiens (Human)

PAX6 Proteins

PAX6 Proteins for Homo sapiens (Human)

PAX6 Proteins for Gallus gallus (Chicken)

PAX6 Proteins for Mus musculus (Mouse)

PAX6 Proteins for Rattus norvegicus (Rat)

PAX6 Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)

PAX6 Proteins for Xenopus laevis (African clawed frog)

PAX6 Proteins for Oryzias latipes (Medaka fish) (Japanese ricefish)

PAX6 Proteins for Bos taurus (Bovine)

PAX6 ELISA Kit

PAX6 ELISA Kit for Mus musculus (Mouse)