PDE4A
PDE4，即磷酸二酯酶4（phosphodiesterase 4），是磷酸二酯酶家族中的一個(gè)重要成員，由4個(gè)同源基因編碼，產(chǎn)生4種亞型：PDE4A、PDE4B、PDE4C和PDE4D。PDE4主要在免疫細(xì)胞和多種炎癥細(xì)胞中表達(dá)，特異性水解細(xì)胞內(nèi)的第二信使環(huán)磷酸腺苷（cAMP），通過調(diào)節(jié)cAMP濃度，引發(fā)下游磷酸化級(jí)聯(lián)反應(yīng)，參與多種生理和病理過程。PDE4的作用機(jī)制是通過其催化活性中心，包含金屬區(qū)和疏水區(qū)，特異性結(jié)合并水解cAMP，從而控制細(xì)胞內(nèi)cAMP的水平。在生物學(xué)意義上，PDE4的活性調(diào)節(jié)與多種疾病密切相關(guān)，包括呼吸系統(tǒng)疾病、自身免疫性疾病、中樞神經(jīng)系統(tǒng)疾病及皮膚病等，因此，PDE4抑制劑的開發(fā)為治療這些疾病提供了新的策略。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA295171(PDE4A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA295171(PDE4A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, A172 cells, Primary antibody: CSB-PA295171(PDE4A Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
PDE4A Antibodies
PDE4A for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA295171 | PDE4A Antibody | Human | ELISA,WB,IHC |
PDE4A Proteins
PDE4A Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP526024MO CSB-EP526024MO CSB-BP526024MO CSB-MP526024MO CSB-EP526024MO-B |
Recombinant Mouse cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Pde4a), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDE4A Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP529584GU CSB-EP529584GU CSB-BP529584GU CSB-MP529584GU CSB-EP529584GU-B |
Recombinant Guinea pig cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
