PECAM1
血小板內(nèi)皮細(xì)胞黏附分子(PECAM1)又稱為CD31,是相對(duì)分子質(zhì)量為130kDa 的I 型跨膜糖蛋白,屬于免疫球蛋白超家族成員。CD31 通常位于血管內(nèi)皮細(xì)胞、血小板、巨噬細(xì)胞和kuffer細(xì)胞、粒細(xì)胞、T/NK細(xì)胞、淋巴細(xì)胞、巨核細(xì)胞、破骨細(xì)胞、嗜中性粒細(xì)胞。在某些腫瘤也發(fā)現(xiàn)CD31的表達(dá),如上皮樣血管內(nèi)皮瘤、上皮樣肉瘤樣血管內(nèi)皮瘤、其他血管腫瘤、組織細(xì)胞性惡性腫瘤和漿細(xì)胞。在循環(huán)血小板和白細(xì)胞中,CD31主要是通過(guò)調(diào)節(jié)其胞內(nèi)結(jié)構(gòu)域磷酸化順序而限制細(xì)胞活化反應(yīng),通常是作為抑制性受體起作用。另外,D31也在內(nèi)皮細(xì)胞細(xì)胞間連接處高度表達(dá),作為機(jī)械傳感器,白細(xì)胞運(yùn)輸?shù)恼{(diào)節(jié)劑和維持內(nèi)皮細(xì)胞連接完整性起作用。與CD31相關(guān)的大多數(shù)活性可歸因于嗜同性CD31-CD31相互作用。其中包括白細(xì)胞外滲、骨髓造血和血管發(fā)育。CD31可以促進(jìn)各種白細(xì)胞相關(guān)整聯(lián)蛋白與ICAM/VCAM IgSF成員的結(jié)合,并幫助外周血白細(xì)胞穿過(guò)內(nèi)皮屏障。促進(jìn)CAM-IgSF結(jié)合是由于白細(xì)胞CD31-內(nèi)皮細(xì)胞CD31參與后,β1和β2整聯(lián)蛋白活性的普遍上調(diào)引起的。
在2015年ASCO會(huì)議上,Michael J. Birrer, MD團(tuán)隊(duì)結(jié)合他們的研究提出CD31是卵巢癌中貝伐單抗療效的潛在標(biāo)志物。因?yàn)樨惙慰箤?duì)無(wú)進(jìn)展生存期和總生存期的影響在高CD31的患者中最為明顯。這一發(fā)現(xiàn)再次引起了國(guó)內(nèi)外學(xué)者對(duì)CD31的關(guān)注。
熱銷產(chǎn)品
CD31 Monoclonal Antibody (ELISA, WB, IHC, IF, FC) (CSB-MA017767A0m)
驗(yàn)證數(shù)據(jù)
Positive WB detected in: Jurkat whole cell lysate, THP-1 whole cell lysate, Raji whole cell lysate
IHC image of CSB-MA017767A0m diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system.
Immunofluorescence staining of Hela cells with CD31 antibody at 1:100, counter-stained with DAPI.
Overlay histogram showing THP-1 cells stained with CD31 antibody (red line) at 1:250.
PECAM1 Antibodies
PECAM1 for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA017767GA01HU | PECAM1 Antibody | Human | ELISA,WB,IHC |
CSB-PA616412 | PECAM1 Antibody | Human | ELISA,WB |
CSB-PA116016 | PECAM1 (Ab-713) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
CSB-PA851852 | PECAM1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA666102 | Phospho-PECAM1 (Y713) Antibody | Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA777657 | PECAM1 Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA982317 | PECAM1 Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA085447 | PECAM1 Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA929097 | PECAM1 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA022257 | PECAM1 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA116222 | PECAM1 Antibody | Human | WB,ELISA |
CSB-PA017767LA01HU | PECAM1 Antibody | Human, Mouse, Rat | ELISA, WB, IHC, IF |
CSB-PA017767LB01HU | PECAM1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA017767LC01HU | PECAM1 Antibody, FITC conjugated | Human | |
CSB-PA017767LD01HU | PECAM1 Antibody, Biotin conjugated | Human | ELISA |
CSB-RA017767A0HU | CD31 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, FC |
CSB-MA017767A0m | CD31 Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC |
PECAM1 Proteins
PECAM1 Proteins for Bos taurus (Bovine)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP017767BO1 CSB-EP017767BO1 CSB-BP017767BO1 CSB-MP017767BO1 CSB-EP017767BO1-B |
Recombinant Bovine Platelet endothelial cell adhesion molecule (PECAM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF017767BO | Recombinant Bovine Platelet endothelial cell adhesion molecule (PECAM1) | in vitro E.coli expression system |
PECAM1 Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP017767HU1 CSB-EP017767HU1 CSB-BP017767HU1 CSB-MP017767HU1 CSB-EP017767HU1-B |
Recombinant Human Platelet endothelial cell adhesion molecule (PECAM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF017767HU | Recombinant Human Platelet endothelial cell adhesion molecule (PECAM1) | in vitro E.coli expression system |
PECAM1 Proteins for Rattus norvegicus (Rat)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP668776RA CSB-EP668776RA CSB-BP668776RA CSB-MP668776RA CSB-EP668776RA-B |
Recombinant Rat Platelet endothelial cell adhesion molecule (Pecam1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PECAM1 Proteins for Sus scrofa (Pig)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP839162PI CSB-EP839162PI CSB-BP839162PI CSB-MP839162PI CSB-EP839162PI-B |
Recombinant Pig Platelet endothelial cell adhesion molecule (PECAM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PECAM1 ELISA Kit
PECAM1 ELISA Kit for Mus musculus (Mouse)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
---|---|---|---|
CSB-E08135m | Mouse soluble platelet endothelial cell adhesion molecule 1,sPECAM-1 ELISA Kit | serum, plasma | 0.78 pg/mL |
PECAM1 ELISA Kit for Rattus norvegicus (Rat)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
---|---|---|---|
CSB-E08134r | Rat soluble platelet endothelial cell adhesion molecule 1,sPECAM-1 ELISA Kit | serum, plasma, tissue homogenates | 0.78 ng/mL |
PECAM1 ELISA Kit for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
---|---|---|---|
CSB-E08133h | Human soluble platelet endothelial cell adhesion molecule 1,sPECAM-1 ELISA Kit | serum, plasma, cell culture supernates | 7.8 pg/mL |