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PKM

PKM,即丙酮酸激酶M,別名PKM2。它是一種由PKM基因編碼的酶,屬于丙酮酸激酶家族成員,在細(xì)胞的糖酵解過(guò)程中發(fā)揮關(guān)鍵作用。PKM的作用機(jī)制涉及催化磷酸烯醇式丙酮酸(PEP)與ADP反應(yīng)生成ATP和丙酮酸,是糖酵解途徑中的一個(gè)關(guān)鍵步驟。PKM在細(xì)胞核和細(xì)胞質(zhì)中均有分布,其活性形式為四聚體。PKM的異常表達(dá)或活性改變與多種疾病有關(guān),尤其是在癌癥中,PKM的表達(dá)水平和活性的調(diào)節(jié)與腫瘤細(xì)胞的代謝重編程和增殖能力有關(guān)。PKM也是代謝疾病和炎癥性疾病研究中的一個(gè)潛在靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Pyruvate kinase PKM (PKM), partial (CSB-EP018072HU1)

驗(yàn)證數(shù)據(jù)

CSB-EP018072HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PKM Antibody (CSB-PA02949A0Rb)

驗(yàn)證數(shù)據(jù)

CSB-PA02949A0Rb

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA02949A0Rb at dilution of 1:100

CSB-PA02949A0Rb

Immunofluorescent analysis of Hela cells using CSB-PA02949A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

PKM Antibodies

PKM for Homo sapiens (Human)

PKM Proteins

PKM Proteins for Felis catus (Cat) (Felis silvestris catus)

PKM Proteins for Oryctolagus cuniculus (Rabbit)

PKM Proteins for Mus musculus (Mouse)

PKM Proteins for Gallus gallus (Chicken)

PKM Proteins for Rattus norvegicus (Rat)

PKM Proteins for Pongo abelii (Sumatran orangutan)

PKM Proteins for Xenopus laevis (African clawed frog)

PKM Proteins for Homo sapiens (Human)

PKM ELISA Kit

PKM ELISA Kit for Homo sapiens (Human)