PLA2R1
PLA2R1的中文全稱是,即磷脂酶A2受體1。別名PLA2R、PLA2-R、PLA2IR、CLEC13C、PLA2G1R。PLA2R1是一種Ⅰ型跨細(xì)胞膜受體,屬于甘露糖受體家族的成員之一。它主要分布在腎小球的足細(xì)胞膜上,在特發(fā)性膜性腎?。↖MN)中,約70%的患者體內(nèi)可檢測到針對PLA2R1的抗體,這些抗體與PLA2R1蛋白結(jié)合,影響了PLA2R1蛋白與可溶性磷脂酶A2的結(jié)合,導(dǎo)致足細(xì)胞發(fā)生病變。PLA2R1的作用機(jī)制涉及激活JAK2激酶,促進(jìn)活性氧(ROS)的積累,這些活性氧誘導(dǎo)細(xì)胞死亡和衰老,從而發(fā)揮抑制腫瘤的作用。在多種癌癥中,PLA2R1的表達(dá)降低,并且已知的致癌基因如HIF2α和c-MYC可以抑制其表達(dá)。PLA2R1在白血病、腎癌和乳腺癌細(xì)胞中通過啟動(dòng)子甲基化的方式被抑制,這是癌細(xì)胞中抑制腫瘤抑制基因表達(dá)的一種經(jīng)典方式。
熱銷產(chǎn)品
Recombinant Human Secretory phospholipase A2 receptor (PLA2R1), partial (CSB-BP623780HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PLA2R1 Antibody (CSB-PA623780LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA623780LA01HU at dilution of 1:100
PLA2R1 Antibodies
PLA2R1 for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA623780LA01HU | PLA2R1 Antibody | Human | ELISA, IHC |
CSB-PA623780LB01HU | PLA2R1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA623780LC01HU | PLA2R1 Antibody, FITC conjugated | Human | |
CSB-PA623780LD01HU | PLA2R1 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA623780ESR1HU | PLA2R1 Antibody | Human | ELISA, WB |
PLA2R1 Proteins
PLA2R1 Proteins for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP623780HU | Recombinant Human Secretory phospholipase A2 receptor (PLA2R1), partial | Yeast |
CSB-EP623780HU | Recombinant Human Secretory phospholipase A2 receptor (PLA2R1), partial | E.coli |
CSB-MP623780HU | Recombinant Human Secretory phospholipase A2 receptor (PLA2R1), partial | Mammalian cell |
CSB-EP623780HU-B |
Recombinant Human Secretory phospholipase A2 receptor (PLA2R1), partial | In Vivo Biotinylation in E.coli |
CSB-BP623780HU | Recombinant Human Secretory phospholipase A2 receptor (PLA2R1), partial | Baculovirus |
PLA2R1 ELISA Kit
PLA2R1 ELISA Kit for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
---|---|---|---|
CSB-E13155h | Human phospholipase A2 receptor 1, 180kDa (PLA2R1) ELISA kit | serum, plasma, tissue homogenates | 0.027 ng/ml |