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PPARA

PPARA,即過氧化物酶體增殖物激活受體α,別名包括PPARα、NR1C1。PPARA是一種核受體,屬于PPAR家族成員之一,由人體細(xì)胞自身的基因編碼。PPARA在肝臟、心臟、骨骼肌、腎臟和棕色脂肪組織等多種組織中表達(dá)。其作用機(jī)制主要是通過與特定的配體結(jié)合,如脂肪酸和其衍生物,激活受體,形成異源二聚體與DNA上的PPAR響應(yīng)元件(PPREs)結(jié)合,調(diào)控下游基因的表達(dá),從而參與脂質(zhì)代謝、能量平衡和細(xì)胞增殖等過程。PPARA在生物學(xué)上的意義非常廣泛,它在調(diào)節(jié)脂肪酸氧化、膽固醇代謝、炎癥反應(yīng)、細(xì)胞分化和腫瘤發(fā)生等方面發(fā)揮關(guān)鍵作用。PPARA的激活可以促進(jìn)線粒體脂肪酸氧化,提高能量代謝效率,降低血漿中的膽固醇和甘油三酯水平,對(duì)抗動(dòng)脈粥樣硬化。此外,PPARA還參與調(diào)節(jié)肝臟的解毒功能,影響藥物和毒物的代謝。PPARA的激動(dòng)劑,如纖維酸類藥物,被廣泛用于治療高脂血癥和相關(guān)心血管疾病。因此,PPARA是代謝性疾病和心血管疾病研究和治療中的一個(gè)重要靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Peroxisome proliferator-activated receptor alpha (PPARA) (CSB-BP018421HU)

驗(yàn)證數(shù)據(jù)

CSB-BP018421HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-BP018421HU

Based on the SEQUEST from database of Baculovirus host and target protein, the LC-MS/MS Analysis result of CSB-BP018421HU could indicate that this peptide derived from Baculovirus-expressed Homo sapiens (Human) PPARA.

CSB-BP018421HU

Based on the SEQUEST from database of Baculovirus host and target protein, the LC-MS/MS Analysis result of CSB-BP018421HU could indicate that this peptide derived from Baculovirus-expressed Homo sapiens (Human) PPARA.

PPARA Antibody (CSB-PA030137)

驗(yàn)證數(shù)據(jù)

CSB-PA030137

Western Blot analysis of 3T3 cells using PPAR-α Polyclonal Antibody

Human peroxisome proliferators activator receptors alpha,PPAR-α ELISA Kit (CSB-E09754h)

驗(yàn)證數(shù)據(jù)

CSB-E09754h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E09754h

規(guī)格:96T/48T

靈敏度:19.5 pg/mL

檢測范圍:78 pg/mL-5000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

PPARA Antibodies

PPARA for Homo sapiens (Human)

PPARA Proteins

PPARA Proteins for Mus musculus (Mouse)

PPARA Proteins for Rattus norvegicus (Rat)

PPARA Proteins for Cavia porcellus (Guinea pig)

PPARA Proteins for Xenopus laevis (African clawed frog)

PPARA Proteins for Phascolarctos cinereus (Koala)

PPARA Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

PPARA Proteins for Homo sapiens (Human)

PPARA ELISA Kit

PPARA ELISA Kit for Homo sapiens (Human)

PPARA ELISA Kit for Rattus norvegicus (Rat)