PTPRC
PTPRC,即蛋白酪氨酸磷酸酶受體C型,它是一種跨膜蛋白酪氨酸磷酸酶,廣泛表達(dá)于T淋巴細(xì)胞、B淋巴細(xì)胞、自然殺傷細(xì)胞(NK細(xì)胞)和巨噬細(xì)胞等免疫細(xì)胞中。PTPRC通過(guò)去磷酸化作用調(diào)節(jié)多種信號(hào)傳導(dǎo)途徑,包括但不限于細(xì)胞生長(zhǎng)、分化、有絲分裂和致癌轉(zhuǎn)化等細(xì)胞過(guò)程。它參與調(diào)控的信號(hào)通路主要有T細(xì)胞受體(TCR)和B細(xì)胞受體(BCR)的信號(hào)傳導(dǎo),通過(guò)與抗原受體復(fù)合物直接相互作用,或激活Src家族激酶,對(duì)抗原受體信號(hào)轉(zhuǎn)導(dǎo)進(jìn)行調(diào)節(jié)。此外,PTPRC還抑制JAK激酶,作為細(xì)胞因子受體信號(hào)轉(zhuǎn)導(dǎo)的調(diào)節(jié)者。在生物學(xué)意義上,PTPRC對(duì)維持免疫系統(tǒng)的正常功能至關(guān)重要,其異常表達(dá)或功能失調(diào)與多種自身免疫疾病和癌癥的發(fā)生發(fā)展有關(guān)。
熱銷產(chǎn)品
Recombinant Human Receptor-type tyrosine-protein phosphatase C (PTPRC),Partial (CSB-EP019049HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PTPRC Recombinant Monoclonal Antibody (CSB-RA019049MA1HU)
驗(yàn)證數(shù)據(jù)
Overlay Peak curve showing 293 cells surface stained with CSB-RA019049MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
PTPRC Antibodies
PTPRC for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA019049KA01HU | PTPRC Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA446974 | Phospho-PTPRC (Ser1007) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA040112 | Phospho-PTPRC (S1007) Antibody | Human,Mouse,Rat | WB, IF, ELISA |
CSB-PA010546 | PTPRC Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA480713 | PTPRC Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA868166 | PTPRC Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-RA019049A0HU | CD45 Recombinant Monoclonal Antibody | Human | ELISA |
CSB-MA019049A0m | CD45 Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC |
CSB-RA019049MA1HU | PTPRC Recombinant Monoclonal Antibody | Human | ELISA, FC |
PTPRC for H
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-MA000202 | PTPRC Monoclonal Antibody | Human | ELISA,WB,IHC |
PTPRC Proteins
PTPRC Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP019049HU | Recombinant Human Receptor-type tyrosine-protein phosphatase C (PTPRC), partial | Yeast |
CSB-EP019049HU | Recombinant Human Receptor-type tyrosine-protein phosphatase C (PTPRC),Partial | E.coli |
CSB-BP019049HU CSB-MP019049HU CSB-EP019049HU-B |
Recombinant Human Receptor-type tyrosine-protein phosphatase C (PTPRC), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTPRC Proteins for Mus musculus (Mouse)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP019049MO CSB-EP019049MO CSB-BP019049MO CSB-MP019049MO CSB-EP019049MO-B |
Recombinant Mouse Receptor-type tyrosine-protein phosphatase C (Ptprc), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTPRC Proteins for Rattus norvegicus (Rat)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP019049RA CSB-EP019049RA CSB-BP019049RA CSB-MP019049RA CSB-EP019049RA-B |
Recombinant Rat Receptor-type tyrosine-protein phosphatase C (Ptprc), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTPRC Proteins for Cyprinus carpio (Common carp)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP864275EQE CSB-EP864275EQE CSB-BP864275EQE CSB-MP864275EQE CSB-EP864275EQE-B |
Recombinant Cyprinus carpio Receptor-type tyrosine-protein phosphatase C (ptprc), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |