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RBMS1

RBMS1,即RNA結(jié)合基序單鏈相互作用蛋白1,別名YC1、MSSP、SCR2、HCC-4、MSSP-1、MSSP-2、MSSP-3、C2orf12等。它是一種在人體中由RBMS1基因編碼的蛋白質(zhì),屬于RNA結(jié)合蛋白家族成員之一。RBMS1的作用機(jī)制涉及結(jié)合單鏈DNA/RNA,具有兩個(gè)核糖核蛋白共有序列(RNP-CS),含有保守基序RNP1和RNP2,這些基序最初在RNA結(jié)合蛋白中描述,并且對(duì)DNA結(jié)合是必需的。RBMS1參與多種生物學(xué)過(guò)程,包括DNA復(fù)制、基因轉(zhuǎn)錄、細(xì)胞周期進(jìn)程和細(xì)胞凋亡 。RBMS1在生物學(xué)上的意義非常廣泛,它不僅參與了基因表達(dá)的調(diào)控,還與腫瘤免疫逃逸、細(xì)胞轉(zhuǎn)移和腫瘤抑制過(guò)程相關(guān)。例如,在三陰性乳腺癌中,RBMS1的下調(diào)能夠阻斷PD-L1免疫檢查點(diǎn),促進(jìn)抗腫瘤免疫 。在非小細(xì)胞肺癌中,RBMS1與m6A閱讀器YTHDF1相互作用,促進(jìn)S100P的翻譯,加速癌細(xì)胞的轉(zhuǎn)移 。此外,RBMS1還通過(guò)調(diào)節(jié)SLC7A11的翻譯控制調(diào)節(jié)肺癌鐵死亡 。這些研究表明,RBMS1在腫瘤發(fā)展和轉(zhuǎn)移中發(fā)揮著重要作用,是腫瘤治療中的潛在靶點(diǎn)。

熱銷產(chǎn)品

RBMS1 Antibody (CSB-PA019440LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA019440LA01HU

Western Blot
Positive WB detected in: NIH/3T3 whole cell lysate
All lanes: RBMS1 antibody at 3.6μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 45, 5 kDa
Observed band size: 45 kDa

CSB-PA019440LA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA019440LA01HU at 1:120, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

RBMS1 Antibodies

RBMS1 for Homo sapiens (Human)

RBMS1 Proteins

RBMS1 Proteins for Homo sapiens (Human)