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RNASEH1

RNASEH1(Ribonuclease H1)是核糖核酸內(nèi)切酶H1內(nèi)切酶。RNASEH1的主要功能是在DNA修復(fù)過程中起作用,特別是在RNA-DNA雜交物的剪切中。它有助于維持基因組穩(wěn)定性,通過消除RNA與DNA的雜交,防止不必要的雜交結(jié)構(gòu)的累積,并保持細(xì)胞的正常功能。研究表明,RNASEH1的突變或缺陷與一種罕見的遺傳性神經(jīng)系統(tǒng)退行性疾病——Aicardi-Goutières綜合征(AGS)相關(guān)。AGS通常伴隨著神經(jīng)系統(tǒng)發(fā)育異常和免疫系統(tǒng)異常,而RNASEH1的異??赡芘c此類癥狀的出現(xiàn)有關(guān)。此外,RNASEH1在細(xì)胞生物學(xué)研究和RNA-DNA雜交相關(guān)領(lǐng)域也具有重要的應(yīng)用潛力。對(duì)RNASEH1的深入研究不僅有助于理解細(xì)胞的核酸代謝和基因組穩(wěn)定性的維持,還可能為治療相關(guān)疾病提供新的治療方法或干預(yù)手段。

熱銷產(chǎn)品

Recombinant Human Ribonuclease H1 (RNASEH1)

驗(yàn)證數(shù)據(jù)

SDS-PAGE
CSB-EP019801HU-SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LC-MS/MS
CSB-EP019801HU LC-MS/MS-1

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP019801HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) RNASEH1.

LC-MS/MS
CSB-EP019801HU LC-MS/MS-2

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP019801HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) RNASEH1.


RNASEH1 Antibodies

RNASEH1 for Homo sapiens (Human)

RNASEH1 Proteins

RNASEH1 Proteins for Mus musculus (Mouse)

RNASEH1 Proteins for Homo sapiens (Human)