RPGR
RPGR(視網(wǎng)膜色素變性GTP酶調(diào)節(jié)劑)是一種重要的蛋白質(zhì),由多個異構(gòu)體組成,通過選擇性剪接生成,包含RLD結(jié)構(gòu)域和CAAX結(jié)構(gòu)域,主要在視網(wǎng)膜光感受器的連接纖毛中發(fā)揮作用。RPGR參與纖毛的生物合成和維護,對視網(wǎng)膜光感受器細(xì)胞的功能至關(guān)重要。此外,RPGR作為RAB37小GTP酶的鳥苷酸交換因子,調(diào)控RAB37活性,影響自噬過程,并與Akt、Erk1/2、粘著斑激酶和Src等信號通路相關(guān),這些通路對細(xì)胞的肌動蛋白應(yīng)力纖維調(diào)節(jié)和細(xì)胞周期進(jìn)程具有重要影響。RPGR參與的信號通路包括纖毛信號通路、細(xì)胞自噬信號通路以及細(xì)胞骨架調(diào)節(jié)信號通路。RPGR的突變與多種遺傳性視網(wǎng)膜疾病有關(guān),使其成為研究和治療相關(guān)視網(wǎng)膜疾病的重要靶點。
熱銷產(chǎn)品
Recombinant Human X-linked retinitis pigmentosa GTPase regulator (RPGR), partial (CSB-MP838814HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
RPGR Antibodies
RPGR for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA020099GA01HU | RPGR Antibody | Human,Mouse,Rat | ELISA,WB,IF |
CSB-PA838814LA01HU | RPGR Antibody | Human | ELISA, WB, IHC, IF |
CSB-PA838814LD01HU | RPGR Antibody, Biotin conjugated | Human | ELISA |
CSB-PA838814LC01HU | RPGR Antibody, FITC conjugated | Human | |
CSB-PA838814LB01HU | RPGR Antibody, HRP conjugated | Human | ELISA |
RPGR Proteins
RPGR Proteins for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP838814HU CSB-EP838814HU CSB-BP838814HU CSB-EP838814HU-B |
Recombinant Human X-linked retinitis pigmentosa GTPase regulator (RPGR), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-MP838814HU | Recombinant Human X-linked retinitis pigmentosa GTPase regulator (RPGR), partial | Mammalian cell |