SLIT2
SLIT2，即分泌型裂隙蛋白2，別名Slit homolog 2 (Drosophila)。它是一種在生物體內(nèi)廣泛表達(dá)的細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)分子，屬于Slit家族成員之一，與Robo家族受體相互作用，在神經(jīng)發(fā)育、血管生成、器官及組織發(fā)育以及干細(xì)胞的增殖調(diào)節(jié)等過(guò)程中發(fā)揮作用。SLIT2的作用機(jī)制涉及與其經(jīng)典受體ROBO家族（ROBO1-4）結(jié)合，發(fā)揮調(diào)控細(xì)胞遷移及增殖等多項(xiàng)機(jī)能 。SLIT2不僅在神經(jīng)系統(tǒng)發(fā)育中起到精確引導(dǎo)軸突生長(zhǎng)和神經(jīng)元遷移的作用，還在腫瘤進(jìn)程中發(fā)揮著作用，如在胰腺導(dǎo)管腺癌的肝轉(zhuǎn)移中，SLIT2-ROBO1信號(hào)軸促進(jìn)了腫瘤細(xì)胞在肝臟的定植和生長(zhǎng)。此外，SLIT2的表達(dá)水平在不同的癌癥組織中與癌癥進(jìn)展相關(guān)，其在腫瘤微環(huán)境中的作用機(jī)制是當(dāng)前研究的熱點(diǎn)之一。
熱銷(xiāo)產(chǎn)品
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA136864(SLIT2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA136864(SLIT2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse bladder tissue, Primary antibody: CSB-PA136864(SLIT2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
Human Slit2 ELISA Kit (CSB-E11038h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E11038h
規(guī)格：96T/48T
靈敏度：0.195 ng/mL
檢測(cè)范圍：0.78 ng/mL-50 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
SLIT2 Antibodies
SLIT2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA021768GA01HU | SLIT2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA245341 | SLIT2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA136864 | SLIT2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
SLIT2 Proteins
SLIT2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP021768HU CSB-EP021768HU CSB-BP021768HU CSB-MP021768HU CSB-EP021768HU-B |
Recombinant Human Slit homolog 2 protein (SLIT2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SLIT2 ELISA Kit
SLIT2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11038h | Human Slit2 ELISA Kit | serum, plasma, tissue homogenates | 0.195 ng/mL |
