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SOST

SOST,即硬化蛋白,別名Sclerostin、VBCH。它是一種由SOST基因編碼的分泌型糖蛋白,屬于Cerberus/Dan家族的骨形態(tài)發(fā)生蛋白(BMP)拮抗劑。SOST在骨骼系統(tǒng)中由骨細(xì)胞產(chǎn)生,具有抗骨形成作用。其作用機(jī)制主要是通過(guò)與LRP5/6受體結(jié)合,抑制Wnt信號(hào)通路,從而對(duì)骨形成產(chǎn)生抑制作用。SOST對(duì)維持骨穩(wěn)態(tài)、骨密度維持和骨折愈合等方面至關(guān)重要,其異常表達(dá)與多種骨骼疾病相關(guān),包括骨質(zhì)疏松癥、骨折愈合障礙以及遺傳性骨疾病如硬化性骨病和van Buchem病等,是治療代謝性骨病和促進(jìn)骨折修復(fù)的潛在治療靶點(diǎn)。

熱銷產(chǎn)品

SOST Recombinant Monoclonal Antibody (CSB-RA858415MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA858415MA1HU

IHC image of CSB-RA858415MA1HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA858415MA1HU

IHC image of CSB-RA858415MA1HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

Human Sclerostin(SOST) ELISA Kit (CSB-E13146h)

驗(yàn)證數(shù)據(jù)

CSB-E13146h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E13146h

規(guī)格:96T/48T

靈敏度:7.8 pg/mL

檢測(cè)范圍:31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

SOST Antibodies

SOST for Homo sapiens (Human)

SOST Proteins

SOST Proteins for Mus musculus (Mouse)

SOST Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

SOST Proteins for Homo sapiens (Human)

SOST Proteins for Rattus norvegicus (Rat)

SOST Proteins for Bos taurus (Bovine)

SOST ELISA Kit

SOST ELISA Kit for Homo sapiens (Human)

SOST ELISA Kit for Rattus norvegicus (Rat)