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STAT6

STAT6,即信號(hào)轉(zhuǎn)導(dǎo)及轉(zhuǎn)錄激活因子6。它是由STAT6基因編碼的一種轉(zhuǎn)錄因子,主要在免疫系統(tǒng)中發(fā)揮作用。STAT6的作用機(jī)制是通過與細(xì)胞因子如IL-4和IL-13的受體結(jié)合,被Janus激酶(JAK)磷酸化后激活,進(jìn)而形成同源或異源二聚體并轉(zhuǎn)位到細(xì)胞核內(nèi),調(diào)控特定基因的表達(dá)。其信號(hào)通路涉及JAK/STAT6途徑,這一途徑在調(diào)節(jié)Th2型免疫反應(yīng)、促進(jìn)B細(xì)胞產(chǎn)生IgE、以及影響細(xì)胞增殖和分化等方面具有重要作用。在生物學(xué)意義上,STAT6對(duì)維持免疫平衡、參與炎癥反應(yīng)和抗寄生蟲免疫等過程至關(guān)重要。STAT6的異常激活與多種疾病相關(guān),包括過敏性疾病如哮喘、以及某些類型的癌癥。

熱銷產(chǎn)品

STAT6 Recombinant Monoclonal Antibody (CSB-RA988543A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA988543A0HU

Western Blot
Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate, HepG2 whole cell lysate, NIH/3T3 whole cell lysate, K562 whole cell lysate
All lanes: STAT6 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 95, 75, 82 kDa
Observed band size: 100 kDa

CSB-RA988543A0HU

IHC image of CSB-RA988543A0HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

STAT6 Antibodies

STAT6 for Homo sapiens (Human)

STAT6 Proteins

STAT6 Proteins for Homo sapiens (Human)

STAT6 Proteins for Mus musculus (Mouse)