STAT6
STAT6，即信號(hào)轉(zhuǎn)導(dǎo)及轉(zhuǎn)錄激活因子6。它是由STAT6基因編碼的一種轉(zhuǎn)錄因子，主要在免疫系統(tǒng)中發(fā)揮作用。STAT6的作用機(jī)制是通過與細(xì)胞因子如IL-4和IL-13的受體結(jié)合，被Janus激酶（JAK）磷酸化后激活，進(jìn)而形成同源或異源二聚體并轉(zhuǎn)位到細(xì)胞核內(nèi)，調(diào)控特定基因的表達(dá)。其信號(hào)通路涉及JAK/STAT6途徑，這一途徑在調(diào)節(jié)Th2型免疫反應(yīng)、促進(jìn)B細(xì)胞產(chǎn)生IgE、以及影響細(xì)胞增殖和分化等方面具有重要作用。在生物學(xué)意義上，STAT6對(duì)維持免疫平衡、參與炎癥反應(yīng)和抗寄生蟲免疫等過程至關(guān)重要。STAT6的異常激活與多種疾病相關(guān)，包括過敏性疾病如哮喘、以及某些類型的癌癥。
熱銷產(chǎn)品
STAT6 Recombinant Monoclonal Antibody (CSB-RA988543A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate, HepG2 whole cell lysate, NIH/3T3 whole cell lysate, K562 whole cell lysate
All lanes: STAT6 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 95, 75, 82 kDa
Observed band size: 100 kDa
IHC image of CSB-RA988543A0HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
STAT6 Antibodies
STAT6 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA022816GA01HU | STAT6 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA073316 | Phospho-STAT6 (Tyr641) Antibody | Human | ELISA,WB,IHC |
| CSB-PA204581 | Phospho-STAT6 (Thr645) Antibody | Human | ELISA,WB,IHC |
| CSB-PA904385 | STAT6 (Ab-641) Antibody | Human | ELISA,WB,IHC |
| CSB-PA596879 | STAT6 (Ab-645) Antibody | Human | ELISA,WB,IHC |
| CSB-PA000624 | Phospho-STAT6 (T645) Antibody | Human,Mouse,Rat | WB, IHC, IP, ELISA |
| CSB-PA004183 | STAT6 Antibody | Human,Mouse,Rat | WB, IHC, IP, ELISA |
| CSB-PA050171 | STAT6 Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA138665 | STAT6 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA171110 | STAT6 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA000625 | Phospho-STAT6 (Y641) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA022816LA01HU | STAT6 Antibody | Human | ELISA, IHC, IF |
| CSB-PA022816LB01HU | STAT6 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA022816LC01HU | STAT6 Antibody, FITC conjugated | Human | |
| CSB-PA022816LD01HU | STAT6 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA988543A0HU | STAT6 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB, IHC |
STAT6 Proteins
STAT6 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022816HU CSB-EP022816HU CSB-BP022816HU CSB-MP022816HU CSB-EP022816HU-B |
Recombinant Human Signal transducer and activator of transcription 6 (STAT6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAT6 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022816MO CSB-EP022816MO CSB-BP022816MO CSB-MP022816MO CSB-EP022816MO-B |
Recombinant Mouse Signal transducer and transcription activator 6 (Stat6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
