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STK11

STK11,即絲氨酸/蘇氨酸激酶11,也被稱為L(zhǎng)KB1(Liver Kinase B1)。它是一種在人體多種組織中表達(dá)的蛋白質(zhì),尤其在肝臟、腎臟和肺組織中。STK11的作用機(jī)制涉及作為蛋白激酶,通過磷酸化絲氨酸和蘇氨酸殘基,調(diào)控多種細(xì)胞過程,包括細(xì)胞極性、細(xì)胞周期、細(xì)胞增殖和細(xì)胞凋亡。STK11是LKB1-AMPK-mTOR信號(hào)通路的關(guān)鍵調(diào)節(jié)因子,通過激活A(yù)MPK(AMP激活蛋白激酶)來抑制mTOR(哺乳動(dòng)物雷帕霉素靶蛋白)信號(hào)通路,從而在能量平衡和細(xì)胞生長(zhǎng)中發(fā)揮作用。在生物學(xué)意義上,STK11作為腫瘤抑制基因,其突變與多種癌癥的發(fā)生發(fā)展有關(guān),特別是在肺腺癌和胃腸道腫瘤中。STK11的活性喪失可能導(dǎo)致細(xì)胞周期失控和腫瘤形成,因此它在癌癥治療中是一個(gè)重要的靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Serine/threonine-protein kinase STK11 (STK11) (CSB-EP624036HU)

驗(yàn)證數(shù)據(jù)

CSB-EP624036HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP624036HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP624036HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) STK11.

CSB-EP624036HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP624036HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) STK11.

STK11 Antibody (CSB-PA003157)

驗(yàn)證數(shù)據(jù)

CSB-PA003157

Western Blot analysis of HT29 cells using LKB1 Polyclonal Antibody

CSB-PA003157

Western Blot analysis of K562 cells using LKB1 Polyclonal Antibody

CSB-PA003157

Western blot analysis of KB 3T3 Hela lysis using LKB1 antibody.

STK11 Antibodies

STK11 for Homo sapiens (Human)

STK11 Proteins

STK11 Proteins for Rattus norvegicus (Rat)

STK11 Proteins for Gallus gallus (Chicken)

STK11 Proteins for Homo sapiens (Human)

STK11 Proteins for Xenopus laevis (African clawed frog)

STK11 Proteins for Mus musculus (Mouse)