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TIGAR

TIGAR,即TP53誘導(dǎo)的糖酵解和凋亡調(diào)節(jié)劑,別名FR2BP、C12orf5。它是一種在細(xì)胞對(duì)p53相關(guān)應(yīng)激反應(yīng)中起重要作用的蛋白,由人體細(xì)胞自身的基因編碼。TIGAR的作用機(jī)制主要是通過抑制糖酵解途徑,增加磷酸戊糖途徑的流量,從而產(chǎn)生更多的NADPH,以促進(jìn)DNA修復(fù)和減少細(xì)胞內(nèi)活性氧(ROS)的產(chǎn)生,保護(hù)細(xì)胞免受氧化應(yīng)激引起的損傷。TIGAR在生物學(xué)上的意義非常廣泛,它參與調(diào)節(jié)細(xì)胞的代謝、氧化還原平衡、細(xì)胞周期、細(xì)胞凋亡以及自噬等過程。TIGAR的表達(dá)與多種疾病的發(fā)生發(fā)展密切相關(guān),尤其是在腫瘤發(fā)展中,TIGAR通過抗氧化作用和調(diào)節(jié)自噬,有助于腫瘤細(xì)胞逃避免疫監(jiān)視和增強(qiáng)腫瘤細(xì)胞的侵襲能力。此外,TIGAR的功能異常還與某些心血管疾病和神經(jīng)退行性疾病相關(guān)。因此,TIGAR是藥物開發(fā)和疾病治療中的一個(gè)潛在靶點(diǎn)。

熱銷產(chǎn)品

TIGAR Antibody (CSB-PA889078LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA889078LA01HU

Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA889078LA01HU at dilution of 1:100

CSB-PA889078LA01HU

Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA889078LA01HU at dilution of 1:100

CSB-PA889078LA01HU

Immunofluorescent analysis of Hela cells using CSB-PA889078LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

TIGAR Antibodies

TIGAR for Homo sapiens (Human)

TIGAR Proteins

TIGAR Proteins for Homo sapiens (Human)