TLR8
TLR8,即Toll樣受體8,別名Toll樣蛋白8。它是一種在人體中由TLR8基因編碼的蛋白質(zhì),屬于Toll樣受體家族成員之一,主要在髓樣細(xì)胞如單核細(xì)胞、樹突細(xì)胞和某些上皮細(xì)胞中表達(dá)。TLR8的作用機(jī)制是通過識別病原體相關(guān)分子模式,如某些細(xì)菌和病毒的核酸成分,激活下游的信號傳導(dǎo)途徑。TLR8的激活通常依賴于MyD88介導(dǎo)的信號通路,進(jìn)而激活NF-κB、MAPK等轉(zhuǎn)錄因子,導(dǎo)致炎癥介質(zhì)和細(xì)胞因子的釋放,從而在先天性免疫和適應(yīng)性免疫中發(fā)揮關(guān)鍵作用 。TLR8在生物學(xué)上的意義非常廣泛,它參與調(diào)節(jié)多種免疫細(xì)胞的活化、增殖和分化過程。TLR8的激活可以促進(jìn)樹突細(xì)胞成熟,增強(qiáng)其抗原呈遞能力,從而激活T細(xì)胞介導(dǎo)的免疫應(yīng)答。此外,TLR8的信號傳導(dǎo)還與炎癥反應(yīng)、細(xì)胞存活和增殖等生理過程密切相關(guān)。TLR8的功能異常與多種疾病有關(guān),包括自身免疫性疾病、慢性炎癥性疾病和某些感染性疾病。因此,TLR8是免疫學(xué)研究和相關(guān)疾病治療中的一個(gè)潛在靶點(diǎn) 。
熱銷產(chǎn)品
Recombinant Human Toll-like receptor 8 (TLR8), partial (CSB-YP023607HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA261777(TLR8 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA261777(TLR8 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
TLR8 Antibodies
TLR8 for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA080187 | TLR8 Antibody | Human,Mouse,Rat | IHC, ELISA |
CSB-PA160291 | TLR8 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA289221 | TLR8 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA268874 | TLR8 Antibody | Human | ELISA,IHC |
CSB-PA261777 | TLR8 Antibody | Human | ELISA,IHC |
TLR8 Proteins
TLR8 Proteins for Mus musculus (Mouse)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP023607MO CSB-EP023607MO CSB-BP023607MO CSB-MP023607MO CSB-EP023607MO-B |
Recombinant Mouse Toll-like receptor 8 (Tlr8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TLR8 Proteins for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP023607HU | Recombinant Human Toll-like receptor 8 (TLR8), partial | Yeast |
CSB-EP023607HU CSB-BP023607HU CSB-MP023607HU CSB-EP023607HU-B |
Recombinant Human Toll-like receptor 8 (TLR8), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |