TMPRSS2
TMPRSS2（Transmembrane Serine Protease 2）是一種跨膜絲氨酸蛋白酶，TMPRSS2主要存在于上皮細(xì)胞中，特別是在肺部、腸道和前列腺等組織中表達(dá)較高。它的一個(gè)重要作用是剪切和活化其他蛋白，尤其是病毒蛋白或其他蛋白前體。在病毒感染中，比如在SARS-CoV-2（導(dǎo)致COVID-19的病毒）感染中，TMPRSS2蛋白可以促進(jìn)病毒進(jìn)入宿主細(xì)胞。在COVID-19研究中，TMPRSS2被認(rèn)為參與了SARS-CoV-2病毒進(jìn)入上皮細(xì)胞的過(guò)程，因此針對(duì)TMPRSS2的研究可能有助于發(fā)展針對(duì)病毒入侵的治療方法。
熱銷產(chǎn)品
Recombinant Human Transmembrane protease serine 2 (TMPRSS2), partial (Active)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Recombinant Human TMPRSS2 His tag protein (CSB-YP023924HU) enzyme activity is measured by its ability to cleave fluorogenic peptide substrate(Boc-Gln-Ala-Arg-AMC), The Km is 21.93μM.
Activity
Measured by Camostat Mesylate inhibit ratio on TMPRSS2 (CSB-YP023924HU), which can cleave fluorogenic peptide substrate (Boc-Gln-Ala-Arg-AMC). The Camostat Mesylate inhibit EC50 is 0.03347-0.07945μM.
TMPRSS2 Antibodies
TMPRSS2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA971239 | TMPRSS2 Antibody | Human | ELISA, WB |
TMPRSS2 Proteins
TMPRSS2 Proteins for Homo sapiens (Human)
TMPRSS2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-BP884918MO CSB-MP884918MO CSB-EP884918MO-B |
Recombinant Mouse Transmembrane protease serine 2 (Tmprss2), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP884918MO | Recombinant Mouse Transmembrane protease serine 2 (Tmprss2), partial | E.coli |
| CSB-YP884918MO | Recombinant Mouse Transmembrane protease serine 2 (Tmprss2), partial | Yeast |
| CSB-YP884918MO | Recombinant Mouse Transmembrane protease serine 2 (Tmprss2), partial | Yeast |
| CSB-YP884918MOc7 | Recombinant Mouse Transmembrane protease serine 2 (Tmprss2), partial | Yeast |
