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TMPRSS2

TMPRSS2(Transmembrane Serine Protease 2)是一種跨膜絲氨酸蛋白酶,TMPRSS2主要存在于上皮細(xì)胞中,特別是在肺部、腸道和前列腺等組織中表達(dá)較高。它的一個(gè)重要作用是剪切和活化其他蛋白,尤其是病毒蛋白或其他蛋白前體。在病毒感染中,比如在SARS-CoV-2(導(dǎo)致COVID-19的病毒)感染中,TMPRSS2蛋白可以促進(jìn)病毒進(jìn)入宿主細(xì)胞。在COVID-19研究中,TMPRSS2被認(rèn)為參與了SARS-CoV-2病毒進(jìn)入上皮細(xì)胞的過(guò)程,因此針對(duì)TMPRSS2的研究可能有助于發(fā)展針對(duì)病毒入侵的治療方法。

熱銷產(chǎn)品

Recombinant Human Transmembrane protease serine 2 (TMPRSS2), partial (Active)

驗(yàn)證數(shù)據(jù)

SDS-PAGE
CSB-YP023924HU-SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA
CSB-YP023924HU ELISA1

Recombinant Human TMPRSS2 His tag protein (CSB-YP023924HU) enzyme activity is measured by its ability to cleave fluorogenic peptide substrate(Boc-Gln-Ala-Arg-AMC), The Km is 21.93μM.

ELISA
CSB-YP023924HU ELISA2

Activity
Measured by Camostat Mesylate inhibit ratio on TMPRSS2 (CSB-YP023924HU), which can cleave fluorogenic peptide substrate (Boc-Gln-Ala-Arg-AMC). The Camostat Mesylate inhibit EC50 is 0.03347-0.07945μM.


TMPRSS2 Antibodies

TMPRSS2 for Homo sapiens (Human)

TMPRSS2 Proteins

TMPRSS2 Proteins for Homo sapiens (Human)

TMPRSS2 Proteins for Mus musculus (Mouse)