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TNC

TNC,即神經(jīng)膠質(zhì)素C,別名Tenascin-C、TN,是一種廣泛分布于細胞外基質(zhì)中的大型糖蛋白,主要由成纖維細胞、內(nèi)皮細胞和平滑肌細胞等分泌。TNC具有獨特的多域結(jié)構(gòu),能夠與多種細胞表面受體(如整合素、Notch受體)及其它細胞外基質(zhì)成分相互作用,通過調(diào)節(jié)細胞粘附、遷移、增殖和分化等過程,參與組織的發(fā)育、重塑及修復。在生理狀態(tài)下,TNC對于維持組織穩(wěn)態(tài)和促進傷口愈合具有重要作用。然而,在病理條件下,如腫瘤發(fā)生發(fā)展過程中,TNC的異常高表達可促進癌細胞的侵襲和轉(zhuǎn)移,參與構(gòu)建有利于腫瘤生長的微環(huán)境,成為疾病進展的關(guān)鍵因素之一。此外,TNC還與慢性炎癥、纖維化等疾病相關(guān),顯示出其在多種生物學過程中的復雜角色。

熱銷產(chǎn)品

Recombinant Human Tenascin (TNC), partial (CSB-RP115094h(C))

驗證數(shù)據(jù)

CSB-RP115094h(C)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-RP115094h(C)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP115094h(C) could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) TNC.

CSB-RP115094h(C)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP115094h(C) could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) TNC.

TNC Antibody (CSB-PA11509A0Rb)

驗證數(shù)據(jù)

CSB-PA11509A0Rb

Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA11509A0Rb at dilution of 1:50

TNC Antibodies

TNC for Homo sapiens (Human)

TNC Proteins

TNC Proteins for Gallus gallus (Chicken)

TNC Proteins for Homo sapiens (Human)

TNC Proteins for Sus scrofa (Pig)

TNC Proteins for Mus musculus (Mouse)

TNC ELISA Kit

TNC ELISA Kit for Mus musculus (Mouse)

TNC ELISA Kit for Homo sapiens (Human)