TNFRSF8
CD30又名Ki-1抗原或腫瘤壞死因子受體超家族成員8(TNFRSF8),是一種跨膜糖蛋白受體。CD30與其配體(CD30L)結(jié)合可激活TNF受體相關(guān)因子(TRAF),進(jìn)而激活不同信號通路,包括TRAF2、TRAF1、TRAF5來激活核因子-κB(NFκB)等等,促進(jìn)細(xì)胞增殖或凋亡。CD30還參與絲裂原激活的蛋白激酶(MAPK)通路,包括ERK1和ERK2,從而在腫瘤細(xì)胞中發(fā)揮抗凋亡和促生存作用。CD30在正常組織中表達(dá)有限,而在多種血液腫瘤呈高表達(dá),尤其在系統(tǒng)性間變性大細(xì)胞淋巴瘤(sALCL)和經(jīng)典型霍奇金淋巴瘤(cHL)呈高度、一致性表達(dá)。CD30的特異性表達(dá)使其具有了良好的成藥性,其中靶向CD30-ADC已經(jīng)大獲成功,2011年8月,CD30-ADC--維布妥昔單抗(brentuximabvedotin)首次在美國上市,用于治療霍奇金淋巴瘤和系統(tǒng)性間變性大細(xì)胞淋巴瘤?;诎邢駽D30細(xì)胞療法的可行性,目前已經(jīng)相繼有多家制藥企業(yè)進(jìn)行了CD30 CAR-T細(xì)胞藥物的研發(fā),國內(nèi)的波睿達(dá)生物、宜明細(xì)胞等均已獲得了相關(guān)發(fā)明專利授權(quán)。
Recombinant Human TNFRSF8 活性蛋白實(shí)驗驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L(CSB-MP023996HU1c9), the EC50 is 14.96-20.25 ng/ml.
TNFRSF8 Antibodies
TNFRSF8 for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA912411 | TNFRSF8 Antibody | Human | ELISA,IHC |
CSB-PA172042 | TNFRSF8 Antibody | Human | ELISA,IHC |
TNFRSF8 Proteins
TNFRSF8 Proteins for Rattus norvegicus (Rat)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP023983RA1 CSB-EP023983RA1 CSB-BP023983RA1 CSB-MP023983RA1 CSB-EP023983RA1-B |
Recombinant Rat Tumor necrosis factor receptor superfamily member 8 (Tnfrsf8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF023983RA | Recombinant Rat Tumor necrosis factor receptor superfamily member 8 (Tnfrsf8) | in vitro E.coli expression system |
TNFRSF8 Proteins for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP023983HU1 CSB-EP023983HU1 CSB-BP023983HU1 CSB-EP023983HU1-B |
Recombinant Human Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-CF023983HU | Recombinant Human Tumor necrosis factor receptor superfamily member 8 (TNFRSF8) | in vitro E.coli expression system |
CSB-MP023983HU1 | Recombinant Human Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), partial (Active) | Mammalian cell |
TNFRSF8 Proteins for Mus musculus (Mouse)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP723348MO CSB-EP723348MO CSB-BP723348MO CSB-MP723348MO CSB-EP723348MO-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 8 (Tnfrsf8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TNFRSF8 ELISA Kit
TNFRSF8 ELISA Kit for Mus musculus (Mouse)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
---|---|---|---|
CSB-E04525m | Mouse Cluster of differentiation 30,CD30 ELISA Kit | 3.9 pg/mL |