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XIAP

XIAP,即X染色體連鎖的凋亡抑制蛋白,別名HILP、IAP 3。它是一種由XIAP基因編碼的蛋白質(zhì),屬于凋亡抑制蛋白家族成員,在多種細(xì)胞類型中表達(dá)。XIAP的作用機(jī)制主要通過直接抑制凋亡蛋白酶,如caspase-3、-7、-9,從而阻斷細(xì)胞凋亡的效應(yīng)階段。XIAP還能通過與Smurf1、Tolloid等蛋白相互作用,參與細(xì)胞周期調(diào)控和發(fā)育過程。XIAP的意義非常廣泛,它參與了細(xì)胞存活、免疫調(diào)節(jié)、細(xì)胞凋亡等多種生理和病理過程。XIAP的異常表達(dá)與某些癌癥的發(fā)生發(fā)展密切相關(guān),使其成為抗腫瘤藥物開發(fā)的潛在靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human E3 ubiquitin-protein ligase XIAP (XIAP) (CSB-EP026193HU)

驗(yàn)證數(shù)據(jù)

CSB-EP026193HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

XIAP Antibody (CSB-PA026193LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA026193LA01HU

Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA026193LA01HU at dilution of 1:100

CSB-PA026193LA01HU

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA026193LA01HU at dilution of 1:100

XIAP Antibodies

XIAP for Homo sapiens (Human)

XIAP Proteins

XIAP Proteins for Homo sapiens (Human)

XIAP Proteins for Xenopus laevis (African clawed frog)

XIAP Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

XIAP Proteins for Mus musculus (Mouse)

XIAP Proteins for Rattus norvegicus (Rat)