Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯(lián)免疫試劑盒
  4. Dog clusterin,CLU ELISA Kit

Dog clusterin,CLU ELISA Kit

  • 中文名稱：
    犬凝聚素(CLU)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E13770c
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥4200/￥3000
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
        CLU，全名Clusterin，是一種分泌型糖蛋白，參與多種生物過程，如細(xì)胞存活、凋亡、脂質(zhì)運(yùn)輸和免疫反應(yīng)等。它在阿爾茨海默病、癌癥和心血管疾病等疾病中可能扮演重要角色。CLU還具有與腫瘤相關(guān)的生物標(biāo)志物的特性，成為了癌癥早期診斷和治療的研究方向之一。
        華美生物所提供的Dog clusterin,CLU ELISA Kit屬于ELISA檢測試劑盒，采用競爭法定量檢測狗血清、血漿、組織勻漿樣本中的CLU，其靈敏度為4.963 ng/mL，檢測范圍為7.813 ng/mL-500 ng/mL。
     
  • 別名：
    CLUClusterin ELISA kit; Glycoprotein 80 ELISA kit; Gp80) [Cleaved into: Clusterin beta chain; Clusterin alpha chain] ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Canis lupus familiaris (Dog) (Canis familiaris)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    7.813 ng/mL-500 ng/mL
  • 靈敏度：
    4.963 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測定原理：
    quantitative
  • 測定方法：
    Competitive
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻(xiàn)

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
    CLU（也稱為apoJ）是一種高度保守的糖蛋白，廣泛存在于多種細(xì)胞類型和組織中。CLU參與了多種生物學(xué)過程，包括細(xì)胞凋亡、炎癥、脂代謝和細(xì)胞遷移等。最近的研究表明，CLU與多種疾病的發(fā)生和發(fā)展有關(guān)，如癌癥、心血管疾病、神經(jīng)系統(tǒng)疾病和肝病等。此外，CLU還可能作為生物標(biāo)志物來評估某些疾病的診斷和預(yù)后。
     
  • 功能：
    Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Following stress, promotes apoptosis. Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3. Plays a role in the clearance of immune complexes that arise during cell injury.
  • 基因功能參考文獻(xiàn)：
    1. Real time RT-PCR and western blotting analysis indicated there was a greater abundance of clusterin in cryptorchid dog testes. Furthermore, clusterin was detected in extracellular regions of cryptorchid dog testes. PMID: 29678567
    2. Clusterin may potentially serve as a marker for chronic spinal cord disease in the dog. PMID: 23990410
    3. The chaperone action of clusterin targets prefibrillar species to inhibit amyloid formation PMID: 17412999
    4. The extracellular chaperone clusterin appears in the cytosol during endoplasmic reticulum stress PMID: 17451556
    5. The chaperone action of clusterin is important in quality control of extracellular protein folding PMID: 19878774
    6. The chaperone clusterin mediates systemic clearance of extracellular misfolded proteins PMID: 21505792
    7. Clusterin is an extracellular holdase-type chaperone PMID: 10066740
    8. The chaperone action of clusterin is like that of the small heat shock proteins PMID: 10694874
    9. The chaperone action of clusterin is independent of ATP PMID: 11123922
    10. Clusterin expression may increase cardiac progenitor cell migration via increasing CXCR4 expression and SDF-1/chemokine receptor signaling in a PI3/Akt-dependent manner. PMID: 20813109

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Secreted. Nucleus. Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Microsome. Endoplasmic reticulum. Mitochondrion. Mitochondrion membrane. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, chromaffin granule.
  • 蛋白家族：
    Clusterin family
  • 數(shù)據(jù)庫鏈接：