Human Interleukin 24(IL-24)ELISA Kit
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中文名稱:人白介素24(IL-24)酶聯(lián)免疫試劑盒
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貨號(hào):CSB-E15840h
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規(guī)格:96T/48T
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價(jià)格:¥3200/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:
This human IL-24 ELISA kit employs the quantitative sandwich enzyme immunoassay technique to measure the levels of human IL-24 in multiple samples, including serum, plasma, or tissue homogenates. It also uses the enzyme-substrate chromogenic reaction to visualize and analyze the analyte levels through the color intensity. The intensity of the colored product is in direct proportion to the IL-24 levels in the sample and is measured at 450 nm through a microplate reader.
IL-24 is expressed primarily in T cells and macrophages. Different concentrations of IL-24 may present completely contrary bioactivity. A low concentration of IL-24 promotes inflammatory cytokine expression, resulting in the proinflammatory response. However, high levels of IL-24 strongly induce apoptosis of cancer cells. IL-24 is a potential anti-tumor agent and affects a broad array of cancers, which selectively inhibits tumor cell growth, invasion, metastasis, and angiogenesis, induces cancer-selective apoptosis, and stimulates an anti-cancer immune response, sensitizes cancer call to therapies.
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別名:C49A ELISA Kit; FISP ELISA Kit; IL 24 ELISA Kit; IL 4 induced secreted protein ELISA Kit; IL-24 ELISA Kit; IL10B ELISA Kit; Il24 ELISA Kit; IL24_HUMAN ELISA Kit; interleukin 24 ELISA Kit; Interleukin-24 ELISA Kit; MDA-7 ELISA Kit; MDA7 ELISA Kit; Melanocyte associated Mda 7 ELISA Kit; Melanoma differentiation association protein 7 ELISA Kit; Melanoma differentiation-associated gene 7 protein ELISA Kit; Mob5 ELISA Kit; ST16 ELISA Kit; Suppression of tumorigenicity 16 (melanoma differentiation) ELISA Kit; Suppression of tumorigenicity 16 ELISA Kit; Suppression of tumorigenicity 16 protein ELISA Kit
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縮寫:
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Uniprot No.:
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種屬:Homo sapiens (Human)
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樣本類型:serum, plasma, tissue homogenates
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檢測(cè)范圍:0.3125 ng/ml- 20ng/ml
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靈敏度:0.078 ng/ml
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反應(yīng)時(shí)間:1-5h
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樣本體積:50-100ul
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檢測(cè)波長:450 nm
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研究領(lǐng)域:Immunology
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測(cè)定原理:quantitative
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測(cè)定方法:Sandwich
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數(shù)據(jù)處理:
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貨期:3-5 working days
引用文獻(xiàn)
- Sinomenine accelerate wound healing in rats by augmentation of antioxidant, anti-inflammatory, immunuhistochemical pathways AA Jabbar,/,2023
- TCDD-induced IL-24 secretion in human chorionic stromal cells inhibits placental trophoblast cell migration and invasion G Liu,Reproductive toxicology,2023
- Estimation of Some Biomarkers in Recovered COVID19 Patients AG Nazzal,Journal of Techniques,2022
- Mesenchymal stem cells derived from iPSCs expressing interleukin-24 inhibit the growth of melanoma in the tumor-bearing mouse model Z Wu,Cancer Cell Int,2020
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.
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基因功能參考文獻(xiàn):
- Results show that iron-induced calcification in vascular smooth muscle cells occurred via IL-24; IL-24 was increased during the calcification process induced by iron, and IL-24 itself caused calcification in the absence of iron. These results confirmed the role of interleukin-24 as a candidate gene that might contribute to calcification in vascular media cells. PMID: 29330517
- These results indicated that low expression of Mda-7/IL-24 along with high expression of C-myb are predictors for poor prognosis of Burkitt lymphoma patients; this outcome suggests that Mda-7/IL-24 and C-myb might be potential targets for clinical treatment of Burkitt lymphoma. PMID: 29415639
- Secretome analysis revealed that Oct4 upregulated interleukin 24 (IL24) expression through STAT3 and NFkappaB signaling, and siRNA against IL24 increased IRinduced senescence, whereas recombinant human IL24 suppressed it. The results of the present study indicated that Oct4 confers IR resistance on breast cancer cells by suppressing IRinduced premature senescence through STAT3- and NFkappaB-mediated IL24 production. PMID: 29749438
- These results suggest that hIL-24 can reverse the cisplatin (DDP)- resistance of lung cancer cells, and that the associated mechanism involves the induction of apoptosis and G2/M-phase arrest through the phosphoinositide3-kinase (PI3K)/AKT signaling pathway, as well as a decrease in drug resistance through P-gp expression PMID: 29048638
- These results indicated that Mda7/IL24 could induce terminal differentiation of B lymphoma cells by regulating the expression of Blimp1 and Bcl6 via altering the P38 MAPK signaling pathway. PMID: 28849038
- These results demonstrate a previously unrecognized role of IL24 in inhibition of translation, mediated through both phosphorylation of eIF2alpha and dephosphorylation of 4E-BP1, and provide the first direct evidence for translation control of gene-specific expression by IL24 PMID: 28461326
- IL-24 inhibits AKT via regulating the HMGA1/miR-222 signaling node in human lung cancer cells and acts as an effective tumor suppressor. PMID: 27602961
- this paper shows that IL-24 represents a potential biomarker of allergic inflammation and a Th2 polarized condition of the epithelium PMID: 26577568
- Low IL24 expression is associated with endometriosis. PMID: 27624484
- IL-20 and IL-24 increased the production of monocyte chemoattractant protein-1 by activated spondyloarthritis synovial fluid monocytes, decreased the production of Dickkopf-1 by SpA fibroblast-like synovial cells and induced mineralization in human osteoblasts; taken together, findings indicate disease-aggravating functions of IL-20 and IL-24 in spondyloarthritis PMID: 28369789
- a novel pathway for mda-7/IL-24-induced caspase-independent apoptosis in neuroblastoma cells mediated through modulation of AIF, ATM, and gamma-H2AX. PMID: 27197168
- mda-7/IL-24 directly regulates miRNA expression in cancer cells and highlights the novelty of the mda-7/IL-24-miR-221-beclin-1 loop in mediating cancer cell-specific death. PMID: 27940575
- LINC00152-mediated oncogenic effects occur in part through the epigenetic silencing of IL24 expression following binding with EZH2. PMID: 28109288
- mechanistic studies, inhibition of SRC and PKCdelta completely ablated the ability of MDA-7/IL-24 to reduce the Bcl-x(L)/(s) mRNA ratio and cell viability. These findings show that Bcl-x(s) expression is an important mediator of MDA-7/IL-24-induced cytotoxicity requiring the SRC/PKCdelta signaling axis in NSCLC cells. PMID: 27519412
- Expression of IL-24 and IGFBP-3 significantly suppressed prostate cancer tumor growth in vivo. PMID: 26323436
- Results suggest that IL-24 exerts a potent suppressive effect on influenza viral replication and can be used in the treatment of influenza infection. PMID: 27687232
- Expression of IL-24 enhanced the sensitivity of B lymphoma cells to chemotherapy agents by altering the expression of multidrug-resistance genes via downregulating GTP-RhoA-ERK signaling pathway PMID: 26883473
- IL20R1 correlated with prognosis of patients with pancreatic cancer, and mediates pancreatic cancer cell growth and migration. It may be a potential biomarker for IL24 molecular-targeted therapy. PMID: 26977011
- The anti-viral effect of IL-24 correlated with caspase-3 activation and could be blocked by a pan-caspase inhibitor and by small interfering RNA (siRNA) directed towards TLR3. PMID: 26367324
- This study demonstrated that IL-19 and IL-24 are associated with the modulation of T-cell responses in filarial infections. PMID: 26486636
- This study indicates that IL-24 upregulates expression and activation of double-stranded RNA-activated protein kinase, further increasing expression and activation of eIF-2alpha, and decreasing Bcl-2 to promote apoptosis. PMID: 26168134
- The association of IL-24 polymorphisms with metabolic and cardiovascular risk factors. PMID: 24552169
- Data show that Adenovirus-mediated interleukin 24 (Ad-IL-24) gene therapy suppresses growth of lung carcinoma cells SPC-A1 both in vitro and in vivo. PMID: 25479732
- gene transfer to drive IL24 expression in chronic myeloid leukemia cell lines resulted in cytotoxicity specifically to cancer cells. PMID: 26097559
- IL-24 may enhance tumor chemosensitivity to cisplatin. PMID: 25778843
- MDA-7/IL-24 inhibits Nrf2-mediated antioxidant response through activation of p38 pathway and inhibition of ERK pathway involved in cancer cell apoptosis. PMID: 25236495
- High expression of IL-24 was significantly correlated with second primary malignancy indicator in head and neck squamous cell carcinoma. PMID: 25091574
- Distribution of interleukin-10 family cytokines in serum and synovial fluid of patients with inflammatory arthritis reveals different PMID: 25178435
- IL-24 has a role in sensitizing melanoma cells to erlotinib through modulation of the Apaf-1 and Akt signaling pathways PMID: 20216471
- The results suggest that IL-24 can induce neuroblastoma cell differentiation and apoptosis and may be a potential therapeutic agent for neuroblastoma. PMID: 23692552
- MDA-7/IL-24: multifunctional cancer killing cytokine. PMID: 25001534
- elevated gene expression in Mexican mestizo patients with active Crohn's disease PMID: 24527982
- These results suggest a possible contribution of IL-24 to squamous cell carcinoma invasion via enhancing focal expression of MMP7. PMID: 24270662
- We found that IL-24 effectively inhibits SH-SY5Y neuroblastoma cell migration and invasion by changing subcellular localization and cellular levels of beta-catenin and regulating the levels of proteins associated with cell migration and invasion PMID: 24084981
- a novel MDA-7/IL-24-GAS3-beta1integrin-fibronectin signaling pathway that suppresses breast cancer growth, is reported. PMID: 23468528
- this study indicates that overexpression of IL-24 gene can significantly promote chemosensitivity in MDR phenotype SGC7901/CDDP gastric cancer cells. PMID: 23982423
- MDA-7/IL-24 has a role in cancer-specific apoptosis through SARI induction PMID: 24282278
- mediates T cell microvesicles-induced mast cell activation; contributes to T cell-mediated skin inflammation PMID: 23768573
- MDA-7/IL-24 overexpression decreased the expression of CD44. PMID: 23722307
- IL-24 was strongly expressed in human psoriatic epidermis. Pharmacological inhibition of NF-kappaB increased IL-24 expression in TNF-stimulated human primary keratinocytes. PMID: 24211183
- The role of mda-7/IL-24 is inhibits decreasing of adhesion and invasion in vitro, blocking cell cycle, down-regulating the expression of ICAM-1, MMP-2/9, CDK1, the phosphorylation of ERK and Akt, NF-kappaB and AP-1 transcription activity. PMID: 23772146
- Our findings demonstrate that MDA-7/IL-24 is be a safe and effective way to eradicate cancers and also potentially establish disease-free survival PMID: 23720015
- This suggests that IL-24 plays a profound role in suppressing tumour lymphangiogenesis, thereby, reducing the likelihood of cancer metastasis via the lymphatic route. PMID: 23546515
- results demonstrate that the inflammatory cytokines TNFalpha and IL24 are direct targets of miR-203 in keratinocytes PMID: 22917968
- Data suggest that IL24 is ubiquitinated and degraded by 26S proteasomes; data from site-directed mutagenesis study suggest that lysine 123 is the major internal lysine involved in ubiquitination of IL24; K123R mutant promotes apoptosis of HeLa cells. PMID: 23078624
- IL-24 appears to promote wound chronicity via its inhibitory effect on the migratory behavior of human keratinocytes, mediated through an AKT-dependent pathway. PMID: 23110359
- this study may provide a novel mechanism of action of IL-24 in cardiovascular disease and indicates that IL-24 is a potential therapeutic agent in VSMC calcification. PMID: 23063979
- IL-24 produced by maternal-fetal interface in human first trimester pregnancy may influence the invasion of trophoblasts and is involved in normal pregnancy. PMID: 18704311
- IL-24 could activate human CD8(+) T cells, driving CD8(+) T cells to produce interferon-gamma (IFN-gamma) and counteract tuberculosis. PMID: 21787878
- Transduction of murine tumors with adenoviruses expressing the human IL-24 gene however suppressed the viability and decreased the tumor growth PMID: 22475191
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亞細(xì)胞定位:Secreted.
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蛋白家族:IL-10 family
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組織特異性:Up-regulated in melanoma cells induced to terminally differentiate.
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