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IL24

IL24,即白細(xì)胞介素24,它是一種由T細(xì)胞、B細(xì)胞、巨噬細(xì)胞和樹突狀細(xì)胞等多種免疫細(xì)胞產(chǎn)生的細(xì)胞因子。IL24屬于IL-10細(xì)胞因子家族,通過與特異性受體復(fù)合體結(jié)合,如IL20RA/IL20RB或IL20RB/IL22RA1,激活下游的JAK-STAT信號(hào)通路,進(jìn)而調(diào)控免疫反應(yīng)和細(xì)胞增殖。其作用機(jī)制包括促進(jìn)腫瘤細(xì)胞凋亡、抑制腫瘤血管生成,以及增強(qiáng)對(duì)放化療的敏感性。在生物學(xué)意義上,IL24具有抗腫瘤活性,其表達(dá)水平與多種腫瘤的低惡性和轉(zhuǎn)移性相關(guān),是腫瘤治療和免疫調(diào)節(jié)的潛在靶點(diǎn)。

熱銷產(chǎn)品

IL24 Antibody (CSB-PA613378LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA613378LA01HU

IHC image of CSB-PA613378LA01HU diluted at 1:1400 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA613378LA01HU

IHC image of CSB-PA613378LA01HU diluted at 1:1400 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IL24 Antibodies

IL24 for Homo sapiens (Human)

IL24 Proteins

IL24 Proteins for Homo sapiens (Human)

IL24 Proteins for Mus musculus (Mouse)

IL24 Proteins for Rattus norvegicus (Rat)

IL24 ELISA Kit

IL24 ELISA Kit for Homo sapiens (Human)