Mouse Netrin-1(NTN1) ELISA kit

Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis.

1. potential effect of Ntn-1 on angiogenesis is further verified by the mouse hindlimb ischemia model, where the pre-activation of hUCB-MSCs with Ntn-1 significantly improved vascular regeneration. These results demonstrate that Ntn-1 plays an important role in the tissue regeneration process of hUCB-MSC via the lipid raft-mediated Inalpha6beta4 signaling pathway. PMID: 27881869
2. Using a Ntn1 conditional knockout, we show that netrin 1, which is released at the pial surface by ventricular zone progenitors is responsible for the CNS confinement of precerebellar neurons. PMID: 29343638
3. Collectively, our results defined netrin-1 as a positive regulator of malignant tumor metastasis in GC by activating the YAP signaling, with potential implications for new approaches to GC therapy. PMID: 29305865
4. Data indicate that the formation of the hypothalamic NPY neural network is regulated at least partly by Netrin-1 signalling during normal in utero brain development in the mouse. PMID: 29121420
5. Our findings suggest that netrin-1 can suppress the growth of PDAC and provide a mechanistic insight into this suppression. PMID: 27034160
6. Diabetes decreases aortic levels of netrin-1. However, overexpression of netrin-1 attenuates diabetes-induced VED and limits the reduction of NO levels, while increasing expression of p-ERK1/2, and suppressing oxidative stress and inflammatory and apoptotic processes PMID: 29059224
7. Ntn1 may play divergent cellular roles despite its conserved expression during canal morphogenesis in chicken and mouse. PMID: 28851705
8. netrin1 provides "hederal" boundaries: a local growth substrate that promotes axon extension, while also preventing local innervation of netrin1-expressing domains. PMID: 28780049
9. netrin-1 degradation products are capable of modulating vascular permeability in diabetic retinopathy PMID: 27400127
10. Blockade of Netrin-1/Unc5b by monoclonal antibodies prevents bone destruction and reduces the severity of K/BxN serum transfer-induced arthritis PMID: 27502509
11. Results suggest that Netrin1/DCC signaling induce neuronal migration in the dorsal spinal cord. PMID: 27784329
12. results show that the classical view that attraction of commissural axons is mediated by a gradient of floor-plate-derived netrin-1 is inaccurate and that netrin-1 primarily acts locally by promoting growth cone adhesion. PMID: 28445456
13. Here, we report that dissociation of UNC5C and polymerized TUBB3, the highly dynamic beta-tubulin isoform in neurons, is essential for netrin-1/UNC5C-promoted axon repulsion. These results not only provide a working model of direct modulation of MTs by guidance cues in growth cone navigation but also help us to understand molecular mechanisms underlying developmental brain disorders associated with TUBB3 mutations. PMID: 28483977
14. Netrin1 does not act as a long-range secreted chemoattractant for commissural spinal axons but instead promotes ventrally directed axon outgrowth by haptotaxis, i.e., directed growth along an adhesive surface. PMID: 28434801
15. Netrin-1(+/-) mice were protected against bleomycin-induced lung fibrosis and fibrocyte accumulation. PMID: 26749424
16. netrin 1 treatment prevented bone erosion in an autoimmune arthritis model and age-related bone destruction. PMID: 27681594
17. Netrin-1 reduced the Abeta1- 40-induced Abeta1-42 increase, increased sAbetaPPalpha, and reversed the Abeta-induced sAbetaPPalpha decrease in vitro; in vivo, induction of netrin-1 expression in PDAbetaPPSwe/Ind transgenic mice resulted in reductions in both Abeta1-42 and Abeta1- 40, and ICV delivery of netrin-1 to PDAbetaPPSwe/Ind mice increased sAbetaPPalpha, decreased Abeta, and improved working memory. PMID: 27060954
18. The Netrin-1 and ephrin-B2 synergistic growth cone responses involve the potentiation of Src family kinase signaling, a common effector of both pathways. PMID: 26633881
19. netrin1 prevented cardiac hypertrophy and heart failure through the negative regulation of the MEKK1-dependent MEKERK1/2 and JNK1/2 signaling pathways. PMID: 26783193
20. The results of this study showed that NTN1 contributes to the formation of the Corpus callosum by promoting the preceding removal of the midline leptomeningeal cells and interhemispheric fusion. PMID: 26397040
21. Akt-FoxO1 signaling pathway plays an essential role during liver regeneration PMID: 26573873
22. netrin-1 loss-of-function causes embryonic lethality. PMID: 26257176
23. Results show that the Netrin-1-induced axon slowdown is mediated by complex Ca2+ dynamics and involves Ca2+ efflux from the ER via the Ryanodine channels PMID: 26190161
24. Netrin-1 haploinsufficiency leads to increased dopamine content in the medial prefrontal cortex. PMID: 26264903
25. FLRT3 is a modulator of Netrin-1 response in developing axons. PMID: 24560577
26. These results identify Netrin-1 as a key regulator of osteoclast differentiation that may be a new target for bone therapies. PMID: 25483983
27. Low levels of Ntn1 can account for persistent attraction to the midline in hypomorphs. By contrast, Ntn1 null mice do not show all of the phenotypes reported for Unc5 receptor mutants, indicating that Ntn1 is not necessarily the dominant ligand for Unc5 family members in vivo and ruling out primary roles in survival or angiogenesis. PMID: 26395479
28. Integration of shallow gradients of Shh and Netrin-1 synergistically guides commissural axons in the growing spinal cord. PMID: 25826604
29. Results suggest that down syndrome cell adhesion molecule collaborates with deleted in colorectal cancer to regulate microtubule dynamics via direct binding to dynamic TUBB3 in Netrin-1-induced axon branching. PMID: 25754961
30. Netrin-1 binds to CD146 with high affinity, inducing endothelial cell activation and downstream signaling in a CD146-dependent manner. PMID: 25656845
31. Overall, these findings suggest that commissural axons use distinct mechanisms to navigate in different CNS regions. PMID: 26290247
32. Small netrin-1-derived peptides are highly effective in protecting the heart against myocardial ischemia-reperfusion injury. PMID: 25924621
33. Combination of netrin-1 and SIAH RNAi may prove to be a substantially effective therapy for myocardial infarction. PMID: 25561546
34. Data indicate the roles of Slit1/Robo1 and Netrin1/DCC signals in positioning motor neuron cell bodies. PMID: 25530182
35. This study reveal novel actions for Netrin-1 and provide evidence for a mechanism through which DA axons can selectively innervate one of two terminal zones in the striatum but have free reign to arborize widely within a terminal zone. PMID: 24867253
36. These data demonstrate robust cardioprotective effect of netrin-1 in vivo, as shown by reduced infarct size and improved cardiac function mediated by netrin-1 receptor DCC. PMID: 24928309
37. netrin-1 expression was simultaneously elevated with an increase of retinal neovascularization. PMID: 25149138
38. This study show that Netrin1 initially attracts callosal pioneering axons derived from the cingulate cortex. PMID: 23302812
39. netrin-1 and DCC are critical for the control of arterial innervation and blood flow regulation in peripheral organs. PMID: 24937433
40. Results indicate that the vagus nerve regulates both netrin-1 and pro-resolving lipid mediators. PMID: 24863066
41. Netrin-1 is expressed in the thymus by both thymic stromal cells and thymocytes. It can mediate cell adhesion and potentiate the chemotaxis for chemokine CXCL12. PMID: 24369474
42. Netrin-1 has a rigid elongated structure containing two receptor-binding sites at opposite ends through which it brings together receptor molecules. PMID: 24876346
43. novel model for the spatial regulation of axon branching by Netrin-1, in which localized plasma membrane expansion occurs via TRIM9-dependent regulation of SNARE-mediated vesicle fusion. PMID: 24778312
44. Netrin-1 is highly expressed in obese but not lean adipose tissue, where it directs the retention of macrophages, promoting inflammation. NTN1 also promotes insulin resistance. PMID: 24584118
45. Netrin 1/Dcc/Unc5 chemotropism contributes to axonal confinement within the central nervous system. PMID: 24449837
46. Full-length and fragmented forms of netrin-1, found in multiple sclerosis lesions, have the capacity to inhibit oligodendrocyte precursor migration. PMID: 23831296
47. These studies demonstrate a protective role for endogenous netrin-1 in attenuating diabetic kidney disease. PMID: 23636509
48. a 1, 9 fold increase of Netrin-1 mRNA two weeks after nerve transection and repair in the nerve segment distal to the injury site. , Netrin-1 plays an important role during peripheral nerve regeneration. PMID: 23388207
49. Model in which subventricular zone progenitors respond to a demyelination lesion by NTN1 secretion that both directly promotes cell emigration and contributes to local angiogenesis, which in turn facilitates progenitor cell emigration from the niche. PMID: 23824572
50. Netrin-1 regulates colon-kidney cross talk through suppression of IL-6 function in a mouse model of colitis. PMID: 23445618

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Secreted. Cytoplasm.

In the embryo, widely expressed in the developing nervous system and in mesodermal tissues.

KEGG: mmu:18208

STRING: 10090.ENSMUSP00000021284

UniGene: Mm.39095