Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ANKS1B Antibody

ANKS1B Antibody

  • 中文名稱：
    ANKS1B兔多克隆抗體
  • 貨號：
    CSB-PA767207ESR1HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA767207ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA767207ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ANKS1B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ANKS1B
  • 別名：
    AIDA antibody; AIDA-1 antibody; Amyloid-beta protein intracellular domain-associated protein 1 antibody; Anks1b antibody; ANKS2 antibody; Ankyrin repeat and sterile alpha motif domain containing 1B antibody; Ankyrin repeat and sterile alpha motif domain-containing protein 1B antibody; ANS1B_HUMAN antibody; Cajalin 2 antibody; E2A-PBX1-associated protein antibody; EB-1 antibody; EB1 antibody; MGC26087 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B protein (999-1248AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.; Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
  • 基因功能參考文獻(xiàn)：
    1. this is the first genetic association study of the relationship between the rs7968606 SNP of ANKS1B and the response of schizophrenia patients to treatment with amisulpride. PMID: 28332719
    2. We provide the first evidence that ANKS1B expression is down regulated in ccRCC tumors relative to patient-matched normal kidney tissue in smokers. PMID: 24479813
    3. AIDA1 PTB domain binds amyloid protein precursorin a similar manner to the X11/Mint PTB domain. PMID: 23799029
    4. Targeted-E2A-PBX1 inhibition leads to reduced expression of the EB-1 and Wnt16b genes; aberrant expression of these genes may be a key step in leukemogenesis in t(1;19)-positive pre-B leukemia. PMID: 16769578
    5. It is clear that some single-nucleotide polymorphisms and haplotypes of the EB-1 gene are associated with genetic difference between diabetic patients with and without nephropathy. PMID: 20578947
    6. EB1 recognizes the nucleotide state of tubulin in the microtubule lattice PMID: 19851462
    7. site-specific translocation and evidence of postnatal origin of the t(1;19) fusion in childhood acute lymphoblastic leukemia PMID: 12415113
    8. Evidence pertaining to leukemogenesis by the well-characterized E2A-fusion protein E2A-PBX1 is reviewed and its mechanistic implications are considered. PMID: 12700034
    9. Amyloid beta-protein precursor expression and secretion are regulated via activation of ERK1/2 by HGF in cells transfected with APP751. PMID: 12837293
    10. AbetaPP and the AIDA-1 proteins interact in vitro, in living cells and, endogenously, in leukemia cell lines;AIDA-1 proteins are expressed at high levels in the brain PMID: 15004329
    11. the interaction between AbetaPP and AIDA-1 is regulated by alternative splicing of the AIDA-1 protein PMID: 15347684
    12. specific EB-1/AIDA-1 isoforms, such as AIDA-1c, may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells PMID: 15862129
    13. The TCR gene rearrangements in childhood B-lineage acute lymphoblastic leukemia was associated with expression of E2A-Pbx1 fusion protein chimeric oncogene. PMID: 16386788
    14. The basic nuclear import signal for AIDA-1 is buried at the interface between the two sterile alpha motif domains. PMID: 19666031

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm.; [Isoform 2]: Nucleus.; [Isoform 3]: Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body.; [Isoform 4]: Nucleus. Note=The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.; [Isoform 6]: Nucleus.
  • 組織特異性：
    Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24600

    OMIM: 607815

    KEGG: hsa:56899

    STRING: 9606.ENSP00000449629

    UniGene: Hs.506458