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  4. Recombinant Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B (ANKS1B), partial

Recombinant Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B (ANKS1B), partial

  • 中文名稱：
    Recombinant Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B(ANKS1B) ,partial,Yeast
  • 貨號：
    CSB-YP767207HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B(ANKS1B) ,partial,Yeast
  • 貨號：
    CSB-EP767207HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B(ANKS1B) ,partial,Yeast
  • 貨號：
    CSB-EP767207HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B(ANKS1B) ,partial,Yeast
  • 貨號：
    CSB-BP767207HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B(ANKS1B) ,partial,Yeast
  • 貨號：
    CSB-MP767207HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ANKS1B
  • Uniprot No.：
  • 別名：
    AIDA; AIDA-1; Amyloid-beta protein intracellular domain-associated protein 1; Anks1b; ANKS2; Ankyrin repeat and sterile alpha motif domain containing 1B; Ankyrin repeat and sterile alpha motif domain-containing protein 1B; ANS1B_HUMAN; Cajalin 2; E2A-PBX1-associated protein; EB-1; EB1; MGC26087
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.; Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
  • 基因功能參考文獻：
    1. this is the first genetic association study of the relationship between the rs7968606 SNP of ANKS1B and the response of schizophrenia patients to treatment with amisulpride. PMID: 28332719
    2. We provide the first evidence that ANKS1B expression is down regulated in ccRCC tumors relative to patient-matched normal kidney tissue in smokers. PMID: 24479813
    3. AIDA1 PTB domain binds amyloid protein precursorin a similar manner to the X11/Mint PTB domain. PMID: 23799029
    4. Targeted-E2A-PBX1 inhibition leads to reduced expression of the EB-1 and Wnt16b genes; aberrant expression of these genes may be a key step in leukemogenesis in t(1;19)-positive pre-B leukemia. PMID: 16769578
    5. It is clear that some single-nucleotide polymorphisms and haplotypes of the EB-1 gene are associated with genetic difference between diabetic patients with and without nephropathy. PMID: 20578947
    6. EB1 recognizes the nucleotide state of tubulin in the microtubule lattice PMID: 19851462
    7. site-specific translocation and evidence of postnatal origin of the t(1;19) fusion in childhood acute lymphoblastic leukemia PMID: 12415113
    8. Evidence pertaining to leukemogenesis by the well-characterized E2A-fusion protein E2A-PBX1 is reviewed and its mechanistic implications are considered. PMID: 12700034
    9. Amyloid beta-protein precursor expression and secretion are regulated via activation of ERK1/2 by HGF in cells transfected with APP751. PMID: 12837293
    10. AbetaPP and the AIDA-1 proteins interact in vitro, in living cells and, endogenously, in leukemia cell lines;AIDA-1 proteins are expressed at high levels in the brain PMID: 15004329
    11. the interaction between AbetaPP and AIDA-1 is regulated by alternative splicing of the AIDA-1 protein PMID: 15347684
    12. specific EB-1/AIDA-1 isoforms, such as AIDA-1c, may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells PMID: 15862129
    13. The TCR gene rearrangements in childhood B-lineage acute lymphoblastic leukemia was associated with expression of E2A-Pbx1 fusion protein chimeric oncogene. PMID: 16386788
    14. The basic nuclear import signal for AIDA-1 is buried at the interface between the two sterile alpha motif domains. PMID: 19666031

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  • 亞細胞定位：
    Cytoplasm.; [Isoform 2]: Nucleus.; [Isoform 3]: Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body.; [Isoform 4]: Nucleus. Note=The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.; [Isoform 6]: Nucleus.
  • 組織特異性：
    Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain
  • 數據庫鏈接：

    HGNC: 24600

    OMIM: 607815

    KEGG: hsa:56899

    STRING: 9606.ENSP00000449629

    UniGene: Hs.506458