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FMO5 Antibody

  • 中文名稱：
    FMO5兔多克隆抗體
  • 貨號(hào)：
    CSB-PA008751GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    FMO5
  • 別名：
    Dimethylaniline monooxygenase [N oxide forming] 5 antibody; Dimethylaniline monooxygenase [N-oxide-forming] 5 antibody; Dimethylaniline oxidase 5 antibody; FMO 5 antibody; FMO5 antibody; FMO5_HUMAN antibody; Hepatic flavin containing monooxygenase 5 antibody; Hepatic flavin-containing monooxygenase 5 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human FMO5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.
  • 基因功能參考文獻(xiàn)：
    1. Report relatively stable FMO5 expression throughout development. PMID: 26839369
    2. Nabumetone and pentoxifylline, two widely used pharmaceuticals, were thereby demonstrated to be efficiently oxidized in vitro by FMO5 to the corresponding acetate esters with high selectivity. PMID: 28783300
    3. absence of the typical characteristic sequence motifs sets human FMO5 apart from all characterized Baeyer-Villiger mono-oxygenases so far. These findings open new perspectives in human oxidative metabolism PMID: 26771671
    4. fmo5 displayed a significant, dominant liver-specific mRNA profile. PMID: 16183778
  • 亞細(xì)胞定位：
    Microsome membrane. Endoplasmic reticulum membrane.
  • 蛋白家族：
    FMO family
  • 組織特異性：
    Expressed in fetal and adult liver.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3773

    OMIM: 603957

    KEGG: hsa:2330

    STRING: 9606.ENSP00000254090

    UniGene: Hs.642706