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KCNQ3 Antibody

  • 中文名稱：
    KCNQ3兔多克隆抗體
  • 貨號：
    CSB-PA012091LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Western Blot
      Positive WB detected in: SH-SY5Y whole cell lysate, K562 whole cell lysate
      All lanes: KCNQ3 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 97, 85 kDa
      Observed band size: 97 kDa
    • Immunofluorescence staining of HepG2 cells with CSB-PA012091LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) KCNQ3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    BFNC 2 antibody; BFNC antibody; BFNC2 antibody; EBN 2 antibody; EBN2 antibody; KCNQ 3 antibody; KCNQ3 antibody; KCNQ3_HUMAN antibody; KQT like 3 antibody; KQT-like 3 antibody; KV7.3 antibody; Potassium channel subunit alpha KvLQT3 antibody; Potassium channel voltage gated subfamily Q member 3 antibody; Potassium voltage gated channel KQT like protein 3 antibody; Potassium voltage gated channel KQT like subfamily member 3 antibody; Potassium voltage gated channel subfamily KQT member 3 antibody; Potassium voltage-gated channel subfamily KQT member 3 antibody; Voltage gated potassium channel subunit Kv7.3 antibody; Voltage-gated potassium channel subunit Kv7.3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Potassium voltage-gated channel subfamily KQT member 3 protein (763-872AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，KCNQ3 Antibody (CSB-PA012091LA01HU)，的標記方式是Non-conjugated。對于KCNQ3 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA012091LB01HU KCNQ3 Antibody, HRP conjugated ELISA
    FITC CSB-PA012091LC01HU KCNQ3 Antibody, FITC conjugated
    Biotin CSB-PA012091LD01HU KCNQ3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability.
  • 基因功能參考文獻：
    1. Phylogenetic analysis, electrostatic potential mapping, in silico docking, electrophysiology, and radioligand binding assays reveal that the anticonvulsant binding pocket evolved to accommodate endogenous neurotransmitters including gamma-aminobutyric acid, which directly activates KCNQ5 and KCNQ3 via W265. PMID: 29748663
    2. Tannic acid activates Kv7.4 and Kv7.3/7.5 K(+) channels resulting in vasodilation. PMID: 26969140
    3. Carboxyl terminus helix C-D linker residues play a role in KCNQ3 current amplitudes by controlling the exit of the KCNQ3 channel from the endoplasmic reticulum. PMID: 26692086
    4. In bipolar disorder patients' prefrontal cortex, Kcnq3 expression was decreased, DNA methylation was decreased, and Kcnq3 mRNA was decreased compared to controls. PMID: 25041603
    5. the clinical and EEG features of this patient further on expand the phenotypic variability of KCNQ3 gene mutations PMID: 25278462
    6. mutations in KCNQ3, similarly to KCNQ2, can be found in patients with more severe phenotypes including intellectual disability PMID: 25524373
    7. We monitored KCNQ2/3 channel currents and translocation of PHPLCdelta1 domains as real-time indicators of PM PI(4,5)P2, and translocation of PHOSH2x2, and PHOSH1 domains as indicators of plasma membrane and Golgi PI(4)P, respectively. PMID: 24843134
    8. This study demonistrated that benign neonatal sleep myoclonus can show autosomal dominant inheritance but not allelic to KCNQ3. PMID: 22447848
    9. KCNQ3 mutations might be involved in families with infantile seizures. PMID: 23360469
    10. Data show that KCNQ3 and KCNE5 mRNA expressions were significantly upregulated in preeclampsia. PMID: 21730298
    11. Different structural determinants, identified at the N and C termini of KCNQ3, prevent the effects of syntaxin 1A and calmodulin, respectively. PMID: 21976501
    12. This study reported that the presence of this uncommon residue at position 315 has a strong impact on the stability of the homotetramers and on channel trafficking. PMID: 20610766
    13. There may be a genetic contribution of this gene in juvenile myoclonic epilepsy in a South Indian population. PMID: 12928862
    14. Several BFNC mutations of KCNQ2 and KCNQ3 disrupt surface expression or polarized surface distribution of KCNQ channels, thereby revealing impaired targeting of KCNQ channels to axonal surfaces as a benign familial neonatal convulsions (BFNC) etiology. PMID: 16735477
    15. ICA-27243 is a novel and selective KCNQ3 potassium channel activator. PMID: 18089837
    16. The expression of KCNQ3 increased in late fetal life to infancy in brain. PMID: 18166285
    17. This study identified a novel missense mutation of KCNQ3, c.988C>T located within exon 6. c.988C>T led to the substitution Cys for Arg in amino acid position 330 (p.R330C) in KCNQ3 potassium channel. PMID: 18249525
    18. A three-dimensional homology model in the W309R mutant indicated that the R side chain of pore helices is too far from the Y side chain of the selectivity filter to interact via hydrogen bonds with each other and stabilize the pore structure. PMID: 18425618
    19. Sequence variations of the KCNQ2 (and KCNQ3)genes may contribute to the etiology of common idiopathic epilepsy syndromes. PMID: 18625963
    20. among the allowed assembly conformations are KCNQ3/4 and KCNQ4/5 heteromers. PMID: 18786918
    21. most wild-type channels are functionally silent, with rearrangements of the pore-loop architecture induced by the presence of a hydroxyl-containing residue at the 315 position "unlocking" the channels into a conductive conformation PMID: 18790849

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  • 相關(guān)疾病：
    Seizures, benign familial neonatal 2 (BFNS2)
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel family, KQT (TC 1.A.1.15) subfamily, Kv7.3/KCNQ3 sub-subfamily
  • 組織特異性：
    Predominantly expressed in brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6297

    OMIM: 121201

    KEGG: hsa:3786

    STRING: 9606.ENSP00000373648

    UniGene: Hs.374023