KCNQ3
KCNQ3，即鉀電壓門控通道亞家族Q成員3，別名Kv7.3、KCNQ2-like protein、KCNQ3 potassium channel等。KCNQ3基因位于人類3號染色體上，編碼的蛋白質(zhì)屬于電壓門控鉀離子通道家族成員。KCNQ3的作用機制是通過形成鉀離子通道，調(diào)節(jié)鉀離子的流動，從而控制細(xì)胞膜電位，維持神經(jīng)元的興奮性。在神經(jīng)系統(tǒng)中，KCNQ3與KCNQ2或KCNQ5等亞單位形成異源四聚體，構(gòu)成M型鉀通道，參與調(diào)節(jié)神經(jīng)元的靜息膜電位和動作電位的復(fù)極化過程。KCNQ3功能異常與多種神經(jīng)系統(tǒng)疾病相關(guān)，如癲癇、神經(jīng)性疼痛等。此外，KCNQ3的表達(dá)和功能也與腫瘤的發(fā)生發(fā)展有關(guān)，是研究和治療相關(guān)疾病的潛在靶點。
熱銷產(chǎn)品
KCNQ3 Antibody (CSB-PA012091LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: SH-SY5Y whole cell lysate, K562 whole cell lysate
All lanes: KCNQ3 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 97, 85 kDa
Observed band size: 97 kDa
Immunofluorescence staining of HepG2 cells with CSB-PA012091LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
KCNQ3 Antibodies
KCNQ3 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA012091LA01HU | KCNQ3 Antibody | Human | ELISA, WB, IF |
| CSB-PA012091LB01HU | KCNQ3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012091LC01HU | KCNQ3 Antibody, FITC conjugated | Human | |
| CSB-PA012091LD01HU | KCNQ3 Antibody, Biotin conjugated | Human | ELISA |
KCNQ3 Proteins
KCNQ3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012091HU CSB-EP012091HU CSB-BP012091HU CSB-MP012091HU CSB-EP012091HU-B |
Recombinant Human Potassium voltage-gated channel subfamily KQT member 3 (KCNQ3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
