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LAMC3 Antibody

  • 中文名稱:
    LAMC3兔多克隆抗體
  • 貨號:
    CSB-PA914944
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from K562 cells and 3T3 cells, using LAMC3 antiobdy.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using LAMC3 antibody.
    • Immunofluorescence analysis of LOVO cells, using LAMC3 antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) LAMC3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human LAMC3.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能:
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • 基因功能參考文獻:
    1. LAMC3 gene variation is associated with oral cavity and pharyngeal cancer. PMID: 27749845
    2. We found statistically significant association with AAO for three genes (WRN, NTN4 and LAMC3) with common associated variants. PMID: 26394601
    3. These data suggest that beta2 and gamma3-containing laminins play an important dose-dependent role in development of the cortical pial basement membrane PMID: 22961762
    4. Recessive LAMC3 mutations cause malformations of occipital cortical development. PMID: 21572413
    5. Laminin isoforms containing the gamma3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains PMID: 18697739

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  • 相關(guān)疾?。?/div>
    Cortical malformations occipital (OCCM)
  • 亞細胞定位:
    Secreted, extracellular space, extracellular matrix, basement membrane.
  • 組織特異性:
    Broadly expressed in: skin, heart, lung, and the reproductive tracts.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6494

    OMIM: 604349

    KEGG: hsa:10319

    STRING: 9606.ENSP00000354360

    UniGene: Hs.201805