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LAMC3 Antibody

  • 中文名稱:
    LAMC3兔多克隆抗體
  • 貨號(hào):
    CSB-PA012737GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    LAMA 1 antibody; LAMA antibody; LAMA1 antibody; LAMB1 antibody; Lamc3 antibody; LAMC3_HUMAN antibody; Laminin A chain antibody; Laminin alpha 1 antibody; Laminin alpha 1 chain antibody; Laminin B1 chain antibody; Laminin subunit beta 1 antibody; Laminin subunit gamma-3 antibody; Laminin-12 subunit gamma antibody; Laminin-14 subunit gamma antibody; Laminin-15 subunit gamma antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Human LAMC3-Specific
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • 基因功能參考文獻(xiàn):
    1. LAMC3 gene variation is associated with oral cavity and pharyngeal cancer. PMID: 27749845
    2. We found statistically significant association with AAO for three genes (WRN, NTN4 and LAMC3) with common associated variants. PMID: 26394601
    3. These data suggest that beta2 and gamma3-containing laminins play an important dose-dependent role in development of the cortical pial basement membrane PMID: 22961762
    4. Recessive LAMC3 mutations cause malformations of occipital cortical development. PMID: 21572413
    5. Laminin isoforms containing the gamma3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains PMID: 18697739

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  • 相關(guān)疾?。?/div>
    Cortical malformations occipital (OCCM)
  • 亞細(xì)胞定位:
    Secreted, extracellular space, extracellular matrix, basement membrane.
  • 組織特異性:
    Broadly expressed in: skin, heart, lung, and the reproductive tracts.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 6494

    OMIM: 604349

    KEGG: hsa:10319

    STRING: 9606.ENSP00000354360

    UniGene: Hs.201805