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NEK11 Antibody

  • 中文名稱：
    NEK11兔多克隆抗體
  • 貨號(hào)：
    CSB-PA844052LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Western blot
      All lanes: NEK11 antibody at 7μg/ml + Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit at 1/10000 dilution
      Predicted band size: 75, 55, 56, 69 kDa
      Observed band size: 75 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA844052LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) NEK11 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NEK11
  • 別名：
    4932416N14Rik antibody; FLJ23495 antibody; NEK11 antibody; NEK11_HUMAN antibody; NEK11S/L antibody; Never in mitosis A-related kinase 11 antibody; NIMA (never in mitosis gene a) related kinase 11 antibody; NIMA (never in mitosis gene a)- related kinase 11 antibody; NIMA related kinase 11L antibody; NIMA related kinase 11S antibody; NIMA-related kinase 11 antibody; NimA-related protein kinase 11 antibody; Serine/threonine-protein kinase Nek11 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase Nek11 protein (245-482AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，NEK11 Antibody (CSB-PA844052LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于NEK11 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA844052LB01HU NEK11 Antibody, HRP conjugated ELISA
    FITC CSB-PA844052LC01HU NEK11 Antibody, FITC conjugated
    Biotin CSB-PA844052LD01HU NEK11 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
  • 基因功能參考文獻(xiàn)：
    1. contributes to response of colorectal cancer cells to genotoxic agents and is essential for survival either with or without exposure to DNA damage PMID: 26501353
    2. Results show that downregulation of NEK11 in drug resistant cells might contribute to drug resistance in ovarian cancer. PMID: 24969318
    3. NEK11 controls degradation of CDC25A by directly phosphorylating CDC25A on residues whose phosphorylation is required for beta-TrCP mediated CDC25A polyubiquitylation and degradation. PMID: 20090422
    4. Nek11 has a role in the S-phase checkpoint downstream of the caffeine-sensitive pathway PMID: 12154088
    5. Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells PMID: 15161910
    6. NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. PMID: 19734889

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  • 亞細(xì)胞定位：
    Nucleus. Nucleus, nucleolus.
  • 蛋白家族：
    Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
  • 組織特異性：
    Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 18593

    OMIM: 609779

    KEGG: hsa:79858

    STRING: 9606.ENSP00000372857

    UniGene: Hs.657336