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OXCT1 Antibody

  • 中文名稱：
    OXCT1兔多克隆抗體
  • 貨號：
    CSB-PA095719
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: CSB-PA095719(OXCT1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    3 oxoacid CoA transferase 1 antibody; 3-oxoacid CoA-transferase 1 antibody; EC 2.8.3.5 antibody; OTTHUMP00000120012 antibody; OTTHUMP00000221550 antibody; OXCT antibody; Oxct1 antibody; SCOT antibody; Scot S antibody; Scot-S antibody; SCOT1_HUMAN antibody; Somatic type succinyl CoA:3 oxoacid CoA transferase antibody; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase antibody; Succinyl CoA:3 ketoacid CoA transferase antibody; Succinyl CoA:3 ketoacid coenzyme A transferase 1 mitochondrial antibody; Succinyl CoA:3 oxoacid CoA transferase antibody; Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human OXCT1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
  • 基因功能參考文獻(xiàn)：
    1. Crystal structure of human SCOT, providing a molecular understanding of the reported mutations based on their potential structural effects. PMID: 23420214
    2. Case Report: Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency causes episodic ketoacidotic crises and no apparent symptoms between them. PMID: 20652411
    3. Data show that the ketone body metabolizing enzymes BDH1, BDH2, OXCT1 and ACAT1 were expressed at the mRNA and protein level in all glioma cell lines. PMID: 21791085
    4. Missense Mutations in succinyl-CoA:3-ketoacid CoA transferase is associated with Ketoacidosis. PMID: 21296660
    5. Results demonstrate that h-Scot-t is a single intronless gene specifically expressed in the testis. PMID: 11756565
    6. In SCOT-deficient patients retaining some residual activity, permanent ketosis may be absent. PMID: 15496607
    7. A 6-bp deletion at the splice donor site of intron 1 resulted in the absence of a full-length mature SCOT mRNA with faint amounts of aberrantly spliced transcripts using a cryptic splice donor site within exon 1. PMID: 16765626
    8. the R268H mutation is a ketoacidosis-causing one PMID: 17706444
    9. liver-specific silencing of the SCOT gene expression may be mediated in part by its 5'-flanking sequence PMID: 18648183
    10. The activities of pyruvate carboxylase (SCOT) were decreased by 65% in pancreatic islets of patients with type 2 diabetes. PMID: 19296078

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  • 相關(guān)疾?。?/div>
    Succinyl-CoA:3-oxoacid CoA transferase deficiency (SCOTD)
  • 亞細(xì)胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    3-oxoacid CoA-transferase family
  • 組織特異性：
    Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8527

    OMIM: 245050

    KEGG: hsa:5019

    STRING: 9606.ENSP00000196371

    UniGene: Hs.278277