OXCT1
OXCT1，即3-氧酸輔酶A轉(zhuǎn)移酶1，這是一種在肝外組織中催化酮體分解代謝的關(guān)鍵酶。OXCT1的主要功能是將酮體乙酰乙酸氧化為乙酰乙酰輔酶A，并最終生成乙酰輔酶A進(jìn)入三羧酸循環(huán)，為細(xì)胞提供能量。OXCT1在多種腫瘤中高表達(dá)，并且其表達(dá)水平與腫瘤的惡性程度正相關(guān)。作用機(jī)制上，OXCT1通過調(diào)節(jié)酮體代謝，特別是β-羥丁酸的水平，影響腫瘤細(xì)胞的代謝和生存。OXCT1還能通過β-羥丁酸介導(dǎo)的酮體代謝穩(wěn)態(tài)調(diào)控SREBP1-TRIM21-NF-κB信號通路，進(jìn)而影響腫瘤細(xì)胞的增殖和存活。在生物學(xué)意義上，OXCT1不僅在能量代謝中發(fā)揮關(guān)鍵作用，而且其在腫瘤發(fā)展中的調(diào)控作用使其成為癌癥治療的潛在靶點(diǎn)。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
OXCT1 Antibody (CSB-PA017306ESR2HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: OXCT1 antibody at 8μg/ml
Lane 1: Mouse heart tissue
Lane 2: Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 57, 14 kDa
Observed band size: 57 kDa
Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA017306ESR2HU at dilution of 1:100
OXCT1 Antibodies
OXCT1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA017306LA01HU | OXCT1 Antibody | Human | ELISA, WB, IHC |
| CSB-PA017306GA01HU | OXCT1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA017306ESR1HU | OXCT1 Antibody | Human, Mouse | ELISA, WB |
| CSB-PA017306ESR2HU | OXCT1 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA095719 | OXCT1 Antibody | Human,Mouse,Rat | ELISA,WB |
OXCT1 Proteins
OXCT1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017306HU CSB-BP017306HU CSB-MP017306HU CSB-EP017306HU-B |
Recombinant Human Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial (OXCT1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP017306HU | Recombinant Human Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial (OXCT1) | E.coli |
