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RAB3GAP2 Antibody, FITC conjugated

  • 中文名稱：
    RAB3GAP2兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA872480LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RAB3GAP2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RAB3GAP2
  • 別名：
    RAB3GAP2 antibody; KIAA0839 antibody; Rab3 GTPase-activating protein non-catalytic subunit antibody; RGAP-iso antibody; Rab3 GTPase-activating protein 150 kDa subunit antibody; Rab3-GAP p150 antibody; Rab3-GAP150 antibody; Rab3-GAP regulatory subunit antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Rab3 GTPase-activating protein non-catalytic subunit protein (277-387AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
  • 基因功能參考文獻：
    1. functionally severe RAB3GAP2 mutations cause Warburg Micro syndrome while hypomorphic RAB3GAP2 mutations can result in the milder Martsolf phenotype PMID: 20967465
    2. Data show that at chemical synapses, Rab3 performs specific functions in synpatic vesicle exocytosis. PMID: 18485483
    3. KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator RAB3GAP2 occurs in a GTP-dependent manner through MADD. PMID: 18849981
  • 相關疾病：
    Martsolf syndrome (MARTS); Warburg micro syndrome 2 (WARBM2)
  • 亞細胞定位：
    Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction.
  • 蛋白家族：
    Rab3-GAP regulatory subunit family
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17168

    OMIM: 212720

    KEGG: hsa:25782

    STRING: 9606.ENSP00000351832

    UniGene: Hs.654849