TYK2 (Ab-1054) Antibody
-
中文名稱:TYK2 (Ab-1054)兔多克隆抗體
-
貨號(hào):CSB-PA906130
-
規(guī)格:¥2024
-
圖片:
-
其他:
產(chǎn)品詳情
-
產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) TYK2 Polyclonal antibody
-
Uniprot No.:
-
基因名:
-
宿主:Rabbit
-
反應(yīng)種屬:Human,Mouse,Rat
-
免疫原:Peptide sequence around aa.1052~1056 (H-E-Y-Y-R) derived from Human TYK2.
-
免疫原種屬:Homo sapiens (Human)
-
克隆類型:Polyclonal
-
純化方式:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
-
濃度:It differs from different batches. Please contact us to confirm it.
-
產(chǎn)品提供形式:Liquid
-
應(yīng)用范圍:ELISA,IHC
-
推薦稀釋比:
Application Recommended Dilution IHC 1:50-1:100 -
Protocols:
-
儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
功能:Non-receptor kinase involved in various processes including cell growth, development, cell migration, innate and adaptive immunity. Plays both structural and catalytic roles in numerous cytokines and interferons signaling. Associates with cytokine and growth factor receptors and activate STAT family members including STAT1, STAT3, STAT4 or STAT6. The heterodimeric cytokine receptor complexes are composed of a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1) which serves as the signal transducing chain harboring STAT docking sites once phosphorylated by TYK2, and a second receptor chain associated either with JAK1 or JAK2. In turn, recruited STATs are phosphorylated, form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes. Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling.
-
基因功能參考文獻(xiàn):
- New ELAVL1-TYK2 fusion gene is oncogenic in acute myeloid leukemia. PMID: 27189703
- TYK2 gene variants do not seem to play an important role in Chagas disease susceptibility and/or chronic Chagas cardiomyopathy PMID: 29304122
- TYK2 polymorphism is not associated with Dermatomyositis /Polymyositis in the Chinese Han population PMID: 28846454
- TYK2 activating mutants and fusion proteins were detected in patients diagnosed with leukaemic diseases suggesting that TYK2 is a potent oncogene. PMID: 26631911
- TYK2 genetic variants are differentially associated with common autoimmune diseases PMID: 27807284
- High TYK2 expression is associated with B-cell lymphoma. PMID: 28716895
- These data indicate that germline activating TYK2 mutations predispose to the development of ALL. PMID: 27733777
- TYK2 rs280519 genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients. PMID: 28704535
- TYK2 is associated with systemic sclerosis susceptibility and reinforce the relevance of the IL-12 pathway in SSc pathophysiology. PMID: 26338038
- Clinical genomic analysis of the current series of NF1-MPNST cases found that TYK2 is a new gene mutated in MPNST. PMID: 27875628
- Results demonstrates that the TYK2 rs2304256 and rs12720356 polymorphisms are associated with susceptibility to rheumatic diseases, rs2304256 polymorphism is associated with systemic lupus erythematous (SLE) in Caucasians, and rs280519 polymorphism is associated with SLE in Caucasians and Asians. [meta-analysis] PMID: 26980740
- demonstration of the single marker association of tyrosine kinase-2 polymorphisms with ulcerative colitis and Crohn's disease in Turkish population. PMID: 25744728
- The TYK2 promoter variant is associated with an overall risk for diabetes. PMID: 26288847
- Genetic associations and gene-gene interactions of IRF5 and TYK2 were significantly detected in Han Chinese with systemic lupus erythematosus PMID: 26294277
- The majority of disease-associated mutations in JAKs map to a pseudokinase domain (JH2), demonstrating its central regulatory function. PMID: 26359499
- the role of TYK2 in the pathogenesis of rheumatoid arthritis PMID: 25849893
- present findings suggest that TYK2 regulates apoptotic and proinflammatory pathways in pancreatic beta-cells via modulation of IFNalpha signaling, subsequent increase in MHC class I protein, and modulation of chemokines such as CXCL10. PMID: 26239055
- Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain. PMID: 25762719
- Data indicate a chimeric fusion involving nucleophosmin NPM1 (5q35) and TYK2 kinase (19p13) that encodes an NPM1-TYK2 protein in cutaneous CD30 antigen-positve lymphoproliferative disorders. PMID: 25349176
- Immune cell dysfunction may contribute to enhancement and maintenance of immune inflammatory and autoimmune responses by production of pathogenic cytokines and immune complexes. The role of Tyk2 in innate and adaptive immune cells is discussed. Review. PMID: 24654603
- In cellular assays, SAR-20347 dose dependently (1 nM-10 muM) inhibited JAK1- and/or TYK2-dependent signaling from the IL-12/IL-23, IL-22, and IFN-alpha receptors. PMID: 25156366
- TYK2 as a novel associated locus for idiopathic inflammatory myopathies. PMID: 24812289
- Here, we report the 2.8-A structure of the two-domain pseudokinase-kinase module from the JAK family member TYK2 in its autoinhibited form. PMID: 24843152
- The crystal structure of a receptor-binding fragment of human TYK2, encompassing the FERM and SH2 domains, in complex with peptide motif from the interferon-alpha receptor chain 1 (IFNAR1) is presented. PMID: 24704786
- Our results indicate that the biological processes that require TYK2 catalytic function in humans are restricted to the IL-12 and IL-23 pathways. PMID: 23894201
- TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility. PMID: 23000200
- Two rare autoimmune disease-associated Tyk2 variants are catalytically impaired but signaling competent. PMID: 23359498
- The rs6445975 polymorphism of phox homology domain containing serine/threonine kinase and the rs2304256 polymorphism of tyrosine kinase 2 are associated with the development of systemic lupus erythematosus in Europeans PMID: 22592861
- The most associated variant in primary biliary cirrhosis was in chromosome 19, a low-frequency nonsynonymous single nucleotide polymorphism in TYK2. PMID: 22961000
- In our pilot study, we discovered significant changes in methylation patterns of genes IL-7, IL-13, IL-17C and TYK2 between henodialysis patients and healthy subjects PMID: 22506826
- This study demonistrated that Rs55762744 is a rare variant of modest effect on multiple sclerosis risk affecting a subset of patients. PMID: 22744673
- Studied the doubly tagged full-length construct, H6-FL-TYK-2-FLAG. In the presence of ATP and a peptide substrate, H6-FL-TYK-2-FLAG showed a marked lag in phosphopeptide product formation. TYK-2 KD showed no such lag. PMID: 22486643
- data highlight the role of TYK2 downregulation in breast cancer cell de-differentitation and initiation of regional metastasis PMID: 22116632
- Association analysis identified five SLE susceptibility genes reaching genome-wide levels of significance : NCF2 ,IKZF1 ,IRF8 ,IFIH1 , and TYK2 PMID: 22046141
- infection of airway epithelial cells with hMPV decreased cellular level of Janus tyrosine kinase (Jak1) and tyrosine kinase 2 (Tyk2) PMID: 21949722
- This meta-analysis demonstrates that autoimmune and inflammatory diseases is associated with TYK2 gene rs34536443 and rs2304256 polymorphisms, but not rs280523, rs280519, rs12720270 and rs12720356. PMID: 21140222
- The consequent effect of SOCS1 inhibition of Tyk2 not only results in a reduced IFN response because of inhibition of Tyk2 kinase-mediated STAT signaling but also negatively impacts IFNAR1 surface expression, which is stabilized by Tyk2. PMID: 21757742
- Data suggest that TYK2 polymorphisms were not associated with systemic lupus erythematosus in Hong Kong Chinese, but that rs2304256 and rs12720270 may be associated with photosensitivity and discoid rash. PMID: 21196586
- The rs34536443 variant effect on multiple sclerosis susceptibility might be mediated by deviating T lymphocyte differentiation toward a Th2 phenotype. PMID: 21354972
- Tyk2 deficiency and clinical manifestations of hyper IgE syndromes (Review) PMID: 21178271
- Siva-1 forms a functional complex with Tyk2 and participates in the transduction of signals that inhibit B lymphocyte growth. PMID: 20727854
- Here, the authors report the crystal structures of TYK2, a first in class structure, and JAK3 in complex with PAN-JAK inhibitors CP-690550 and CMP-6, both of which bind in the ATP-binding cavities of both JAK isozymes. PMID: 20478313
- Single-nucleotide polymorphism in TYK2 gene is confirmed to be associated with multiple sclerosis. PMID: 19888296
- rs2304256 associated with increased risk of discoid lupus erythematosus PMID: 19758313
- Studies indicate that the highest T1D association was at marker rs2304256 (odds ratio (OR) = 0.86; 95%CI = 0.82-0.90) in the TYK2 gene 19p13.2See TYK2 gene at chromosome 19p13.2. PMID: 19966805
- Data show that Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. PMID: 12554654
- evidence that the small GTPases RhoA and Rac1, but not Cdc42, are directly associated with Tyk2 and PI3-K in an uPA/uPAR-dependent fashion and are necessary to mediate the uPA/uPAR-directed migration via the Tyk2/PI3-K signalling complex in human VSMC PMID: 12719789
- Catalytically active Tyk2 is necessary for Janus kinase 2 phosphorylation and association with the platelet-activating factor receptor. PMID: 14500680
- In the IFN signaling pathway leading to STAT activation, both JAK1 and TYK2 are essential, whereas NF-kappaB activation requires only TYK2. PMID: 15883164
- mutations in the JAK1 and Tyk2 genes may be identified as initial molecular defects in human cancers and autoimmune diseases PMID: 16239216
顯示更多
收起更多
-
相關(guān)疾病:Immunodeficiency 35 (IMD35)
-
蛋白家族:Protein kinase superfamily, Tyr protein kinase family, JAK subfamily
-
組織特異性:Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
-
數(shù)據(jù)庫(kù)鏈接:
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-